肠道细菌:人类病症的致病因子。

IF 4.6 2区 医学 Q2 IMMUNOLOGY Frontiers in Cellular and Infection Microbiology Pub Date : 2024-10-08 eCollection Date: 2024-01-01 DOI:10.3389/fcimb.2024.1291148
Md Minarul Islam, Nasir Uddin Mahbub, Seong-Tshool Hong, Hea-Jong Chung
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引用次数: 0

摘要

肠道细菌通过与宿主的免疫和生理系统发生复杂的相互作用,在多种人类疾病中扮演着关键的病原体角色,其影响超出了它们的存在本身,还会影响疾病的发生、发展和严重程度。全面了解这些微生物之间的相互作用,对于提高我们对疾病发病机理的认识和创造有针对性的治疗方法至关重要。初步数据显示,纠正微生物失衡可能为疾病预防和治疗方法开辟新途径。根据最近的研究,肠道微生物群在许多健康问题的发病机制中发挥着不可或缺的作用,包括代谢、神经、肾脏、心血管、胃肠道问题以及 COVID-19。微生物组在疾病发病机制中的作用与遗传变量的作用不相上下,这凸显了微生物组在疾病发病机制中的重要意义。本综述探讨了肠道微生物组对人类疾病的病因学贡献、其与宿主的相互作用以及前瞻性治疗方法的开发。为了充分利用肠道微生物组动态对改善人类健康的益处,未来的研究应解决现有的方法学难题,并加深我们对微生物相互作用的了解。
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Gut bacteria: an etiological agent in human pathological conditions.

Through complex interactions with the host's immune and physiological systems, gut bacteria play a critical role as etiological agents in a variety of human diseases, having an impact that extends beyond their mere presence and affects the onset, progression, and severity of the disease. Gaining a comprehensive understanding of these microbial interactions is crucial to improving our understanding of disease pathogenesis and creating tailored treatment methods. Correcting microbial imbalances may open new avenues for disease prevention and treatment approaches, according to preliminary data. The gut microbiota exerts an integral part in the pathogenesis of numerous health conditions, including metabolic, neurological, renal, cardiovascular, and gastrointestinal problems as well as COVID-19, according to recent studies. The crucial significance of the microbiome in disease pathogenesis is highlighted by this role, which is comparable to that of hereditary variables. This review investigates the etiological contributions of the gut microbiome to human diseases, its interactions with the host, and the development of prospective therapeutic approaches. To fully harness the benefits of gut microbiome dynamics for improving human health, future research should address existing methodological challenges and deepen our knowledge of microbial interactions.

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来源期刊
CiteScore
7.90
自引率
7.00%
发文量
1817
审稿时长
14 weeks
期刊介绍: Frontiers in Cellular and Infection Microbiology is a leading specialty journal, publishing rigorously peer-reviewed research across all pathogenic microorganisms and their interaction with their hosts. Chief Editor Yousef Abu Kwaik, University of Louisville is supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Cellular and Infection Microbiology includes research on bacteria, fungi, parasites, viruses, endosymbionts, prions and all microbial pathogens as well as the microbiota and its effect on health and disease in various hosts. The research approaches include molecular microbiology, cellular microbiology, gene regulation, proteomics, signal transduction, pathogenic evolution, genomics, structural biology, and virulence factors as well as model hosts. Areas of research to counteract infectious agents by the host include the host innate and adaptive immune responses as well as metabolic restrictions to various pathogenic microorganisms, vaccine design and development against various pathogenic microorganisms, and the mechanisms of antibiotic resistance and its countermeasures.
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