0.005% 拉坦前列素局部治疗对视神经头和黄斑微血管变化的影响。

IF 2.1 4区 医学 Q2 OPHTHALMOLOGY Indian Journal of Ophthalmology Pub Date : 2024-11-01 Epub Date: 2024-10-25 DOI:10.4103/IJO.IJO_648_24
Büşra D Yıldırım Erdal, Gözde Hondur, Serdar Bayraktar, Ufuk Elgin, Emine Şen
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引用次数: 0

摘要

目的:这项前瞻性研究旨在评估 0.005% 拉坦前列素局部治疗对原发性开角型青光眼(POAG)黄斑和视神经头(ONH)微血管的影响:方法:31 名受试者的 57 只眼睛被纳入研究。方法:31 名受试者的 57 只眼睛在治疗前、治疗第 1 个月和第 3 个月使用光学相干断层血管造影术测量了视神经头全图(wiVD)、毛细血管周围(ppVD)和黄斑血管密度(VD)参数:治疗后眼压明显降低,第 1 个月降低了 17.0 ± 2.3 mmHg,第 3 个月降低了 16.3 ± 2.5 mmHg(P < 0.001)。治疗后第1个月,视网膜上皮细胞wiVD和ppVD显著增加(均为P = 0.001),但在第3个月有所减少,恢复到基线水平(均为P < 0.001),表明已恢复到治疗前水平(均为P > 0.05)。同样,黄斑 wiVD 和黄斑周围 VD(pefVD)在第 1 个月显著增加(分别为 P = 0.013 和 P <0.001),但到第 3 个月又恢复到基线水平(均为 P <0.001)。治疗前和治疗后第 3 个月的黄斑 wiVD 和 pefVD 没有明显差异(P 均 > 0.05)。在随访期间,深部毛细血管丛和眼窝无血管区的参数没有变化(P>0.05):结论:局部使用 0.005% 拉坦前列素能使眼压急剧下降,因此眼底和毛细血管周围血管扩张以及黄斑部血管扩张最初都有所增加。然而,持续差异在第 3 个月时减小,这表明视网膜上皮和视网膜微血管通过代偿机制适应了降低的眼压。
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The effects of topical latanoprost 0.005% treatment on microvascular changes in the optic nerve head and macula.

Purpose: This prospective study aimed to assess the impact of topical latanoprost 0.005% treatment on the microvasculature of the macula and optic nerve head (ONH) in primary open-angle glaucoma (POAG).

Methods: Fifty-seven eyes of 31 subjects were enrolled. ONH whole-image (wiVD), peripapillary (ppVD), and macular vascular density (VD) parameters were measured using optical coherence tomography angiography before treatment, at the 1st month, and at the 3rd month of treatment.

Results: There was a significant reduction in IOP post treatment, with a decrease of 17.0 ± 2.3 mmHg in the 1st month and 16.3 ± 2.5 mmHg in the 3rd month (P < 0.001 for both). ONH wiVD and ppVD significantly increased at the post-treatment 1st month (P = 0.001 for both) but decreased by the 3rd month, returning to baseline levels (P < 0.001 for both), indicating a return to pre-treatment levels (P > 0.05 for both). Similarly, macular wiVD and perifoveolar VD (pefVD) increased significantly at the 1st month (P = 0.013 and P < 0.001, respectively) but returned to baseline by the 3rd month (P < 0.001 for both). No significant difference was observed between before-treatment and post-treatment 3rd month regarding the macular wiVD and pefVD (P > 0.05 for both). Deep capillary plexus and foveal avascular zone parameters did not change during follow-up (P > 0.05 for both).

Conclusion: The initial increase in ONH and peripapillary VD, as well as macular VD, is attributed to the acute reduction in IOP from topical latanoprost 0.005%. However, the diminishment of sustained differences by the 3rd month indicates adaptation of the ONH and retinal microvasculature to decreased IOP through compensatory mechanisms.

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来源期刊
CiteScore
3.80
自引率
19.40%
发文量
1963
审稿时长
38 weeks
期刊介绍: Indian Journal of Ophthalmology covers clinical, experimental, basic science research and translational research studies related to medical, ethical and social issues in field of ophthalmology and vision science. Articles with clinical interest and implications will be given preference.
期刊最新文献
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