2015-2021 年亚兹德大区成年居民甲状腺功能减退症的患病率、发病率和风险因素:亚兹德健康研究结果

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Iranian Journal of Medical Sciences Pub Date : 2024-10-01 DOI:10.30476/ijms.2023.99865.3208
Masoumeh Khosravi, Reyhaneh Azizi, Hossein Fallahzadeh, Masoud Mirzaei
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引用次数: 0

摘要

背景:甲状腺激素水平的任何异常变化都会导致甲状腺疾病,包括甲状腺功能亢进症、甲状腺功能减退症、甲状腺肿等。最近的研究报告显示,甲状腺疾病在全球的流行率和发病率不断上升。本研究旨在确定甲状腺功能减退症的患病率、发病率以及与这种疾病相关的风险因素:本研究分析了一项综合性前瞻性队列研究的数据,该研究收集了亚兹德(伊朗)10,000 人在 6 年内(2015-2021 年)的数据。医生诊断并报告甲状腺功能减退症。数据处理和准备使用 SQL18 和 Excel,数据分析使用 STATA17 和 SPSS22 软件。在 0.05 的显著性水平下进行了描述性统计、逻辑回归和卡方检验:甲状腺功能减退症的患病率为 93/1000,发病率为 15/1000。女性患甲状腺功能减退症的几率是男性的五倍(调整后的OR=5.31,95% CI=3.06-9.19;未调整的OR=6.28,95% CI=3.90-10.12),她们通常在30至39岁之间发病。少吃(加碘)盐也会增加甲状腺功能减退症的风险(未调整OR=1.47,95% CI=1.02-2.11)。铁补充剂(未调整 OR=2.09,95% CI=1.26-3.48)被认为是重要的风险因素之一。根据我们在未调整模型中的发现,每天刷牙一次或两次会增加患甲状腺功能减退症的几率(OR=1.89,P=0.008;OR=2.12,P=0.016)。吸烟(未经调整的OR=0.29,95% CI=0.107-0.786)也是需要进一步调查的因素之一:甲状腺功能减退症在我国人口中的增长趋势令人担忧。结论:甲状腺功能减退症在我国人口中的增长趋势令人担忧,尤其是在育龄妇女中的高发病率值得注意。
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Prevalence, Incidence, and Risk Factors of Hypothyroidism in Adult Residents of Yazd Greater Area, 2015-2021: Results of Yazd Health Study.

Background: Any abnormal change in thyroid hormone levels leads to thyroid disorders, including hyperthyroidism, hypothyroidism, goiter, and so on. Recent studies have reported an increasing prevalence and incidence of thyroid disorders worldwide. This study aims to determine the hypothyroid prevalence, incidence, and risk factors related to this disorder.

Methods: Data from a comprehensive prospective cohort study, collected from a population of 10,000 Yazd (Iran) individuals over a period of 6 years (2015-2021) was analyzed. Physicians diagnosed hypothyroidism and reported it. Data processing and preparation were performed using SQL18 and Excel, while STATA17 and SPSS22 software were employed for data analysis. Descriptive statistics, logistic regression, and Chi-square tests were conducted at a significance level of 0.05.

Results: The prevalence of hypothyroidism was found to be 93/1000, and the incidence was 15/1000 of the population, respectively. Women had five folds more chance of hypothyroidism (adjusted OR=5.31, 95% CI=3.06-9.19 vs. unadjusted OR=6.28, 95% CI=3.90-10.12), and they usually developed it between the ages of 30 and 39. Eating less (iodized) salt also increased the risk of hypothyroidism (unadjusted OR=1.47, 95% CI=1.02-2.11). Iron supplementation (unadjusted OR=2.09, 95% CI=1.26-3.48) was identified as one of the significant risk factors. Based on our findings in the unadjusted model, tooth brushing once or twice a day increases the chance of hypothyroidism (OR=1.89, P=0.008, and OR=2.12, P=0.016, respectively). Tobacco smoking (unadjusted OR=0.29, 95% CI=0.107-0.786) was also among the factors that need further investigation.

Conclusion: The increasing trend of hypothyroidism is concerning in our population. The high prevalence, particularly among women of childbearing age, is notable.

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来源期刊
Iranian Journal of Medical Sciences
Iranian Journal of Medical Sciences MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
0.00%
发文量
84
审稿时长
12 weeks
期刊介绍: The Iranian Journal of Medical Sciences (IJMS) is an international quarterly biomedical publication, which is sponsored by Shiraz University of Medical Sciences. The IJMS intends to provide a scientific medium of com­muni­cation for researchers throughout the globe. The journal welcomes original clinical articles as well as clinically oriented basic science re­search experiences on prevalent diseases in the region and analysis of various regional problems.
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