使用手持式扫源光学相干断层扫描半自动分析早产儿和足月儿的穹顶形黄斑

IF 5 2区 医学 Q1 OPHTHALMOLOGY Investigative ophthalmology & visual science Pub Date : 2024-10-01 DOI:10.1167/iovs.65.12.35
Joshua N Dang, Jolan Wu, Yujiao Zheng, Jason J Bunk, Emily K Tam, Karen E Lee, Sumner E Lawson, Tatiana R Monger, Alex T Legocki, John P Kelly, Obiageri Egeolu, Leona Ding, Ruikang K Wang, Kristina Tarczy-Hornoch, Michelle T Cabrera
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引用次数: 0

摘要

目的:众所周知,穹隆形黄斑(DSM)会出现在高度近视的成年人身上,最近也出现在早产儿身上。本研究使用研究性手持扫源光学相干断层扫描(SS-OCT)来进一步确定婴儿穹隆黄斑的特征:在这项前瞻性观察研究中,对接受早产儿视网膜病变筛查的早产儿和出生后 72 小时内的足月儿进行了成像。两名训练有素的分级人员评估黄斑特征,包括 DSM、视网膜下积液和黄斑水肿。半自动程序测量眼窝不成熟度、穹隆高度和直径:共对 50 名足月儿和 30 名早产儿(46% 为女性,早产儿出生体重为 1038±335 克,胎龄为 28.7±3.1 周)进行了 217 次成像。发生 DSM 的早产儿占 40%,而足月儿占 14%(P = 0.01)。早产儿和足月儿首次确诊 DSM 的平均月龄分别为 38.4 ± 0.0 周和 40.4 ± 1.1 周(P < 0.001)。早产儿的穹顶高度和直径分别为 55.67 ± 44.22 µm 和 3583.15 ± 1090.35 µm,而足月儿的穹顶高度和直径分别为 88.37 ± 44.73 µm 和 3581.97 ± 355.07 µm(P = 0.24 和 P = 0.96)。所有 27 张三维分析图像(早产儿 11 张,足月儿 7 张)均为圆顶结构。没有发现其他关联,包括黄斑积液(P = 0.17):结论:婴儿经常出现 DSM,但与黄斑积液无关。早产儿比足月儿更容易出现 DSM。与儿童和成人的 DSM 不同,婴儿的 DSM 形态多为圆形,而非脊状。
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Semi-Automated Analysis of Dome-Shaped Macula in Preterm and Full-Term Infants Using Handheld Swept-Source Optical Coherence Tomography.

Purpose: Dome-shaped macula (DSM) is known to occur in highly myopic adults and, recently, preterm infants. This study uses investigational handheld swept-source optical coherence tomography (SS-OCT) to further characterize infantile DSM.

Methods: In this prospective, observational study, preterm infants undergoing retinopathy of prematurity screening and full-term infants within 72 hours of birth were imaged. Two trained graders assessed macular features, including DSM, subretinal fluid, and macular edema. A semi-automated program measured foveal immaturity, dome height, and diameter.

Results: Two hundred seventeen imaging sessions from 50 full-term and 30 preterm infants were included (46% female, preterm birth weight 1038 ± 335 g, and gestational age 28.7 ± 3.1 weeks). DSM occurred in 40% preterm versus 14% full-term infants (P = 0.01). Mean postmenstrual age at first DSM diagnosis was 38.4 ± 0.0 weeks among preterm and 40.4 ± 1.1 weeks among full-term infants (P < 0.001). Dome height and diameter measured 55.67 ± 44.22 µm and 3583.15 ± 1090.35 µm for preterm versus 88.37 ± 44.73 µm and 3581.97 ± 355.07 µm for full-term infants (P = 0.24 and P = 0.96, respectively). All 27 images (11 preterm and 7 full-term infants) with 3-dimensional analysis had round dome configuration. No other associations were seen, including macular fluid (P = 0.17).

Conclusions: Infants frequently exhibit DSM without an association with macular fluid. Preterm infants were more likely than full-term infants to have DSM. Unlike DSM in children and adults, infantile DSM configuration is mostly round rather than ridge-shaped.

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来源期刊
CiteScore
6.90
自引率
4.50%
发文量
339
审稿时长
1 months
期刊介绍: Investigative Ophthalmology & Visual Science (IOVS), published as ready online, is a peer-reviewed academic journal of the Association for Research in Vision and Ophthalmology (ARVO). IOVS features original research, mostly pertaining to clinical and laboratory ophthalmology and vision research in general.
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