化学预处理桧木致密化,用于骨合成骨植入物的潜力。

IF 5 3区 医学 Q1 ENGINEERING, BIOMEDICAL Journal of Functional Biomaterials Pub Date : 2024-09-28 DOI:10.3390/jfb15100287
Laura Andze, Vadims Nefjodovs, Martins Andzs, Marite Skute, Juris Zoldners, Martins Kapickis, Arita Dubnika, Janis Locs, Janis Vetra
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引用次数: 0

摘要

这项研究的目的是对桧木进行处理,以获得密度和机械性能与骨骼相当的木质材料,从而生产出一种可用于骨合成骨植入物的材料。第一步,通过牛皮纸蒸煮法对木材样本进行部分脱木质处理。第二步是用乙醇、乙醇-水混合物、生理盐水和水进行提取,以防止可溶性化合物的释放,提高生物相容性。最后一步是在 100 °C 的温度下进行 24 小时的热致密化处理。在干燥状态下获得的结果与骨的特性相当。与未经化学处理的致密化木材相比,经过化学预处理的致密化木材的膨胀程度有所降低。通过体外细胞检测,样品没有显示出细胞毒性。研究结果表明,通过部分脱木质、提取和致密化处理,可以获得无细胞毒性的木材样本,其机械性能相当于骨骼。不过,要确保材料的形状稳定性、防水性和减少膨胀,还需要进一步的研究。
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Chemically Pretreated Densification of Juniper Wood for Potential Use in Osteosynthesis Bone Implants.

The aim of the study was to perform treatment of juniper wood to obtain wood material with a density and mechanical properties comparable to bone, thus producing a potential material for use in osteosynthesis bone implants. In the first step, partial delignification of wood sample was obtained by Kraft cooking. The second step was extraction with ethanol, ethanol-water mixture, saline, and water to prevent the release of soluble compounds and increase biocompatibility. In the last step, the thermal densification at 100 °C for 24 h was implemented. The results obtained in the dry state are equivalent to the properties of bone. The swelling of chemically pre-treated densified wood was reduced compared to chemically untreated densified wood. Samples showed no cytotoxicity by in vitro cell assays. The results of the study showed that it is possible to obtain noncytotoxic wood samples with mechanical properties equivalent to bones by partial delignification, extraction, and densification. However, further research is needed to ensure the material's shape stability, water resistance, and reduced swelling.

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来源期刊
Journal of Functional Biomaterials
Journal of Functional Biomaterials Engineering-Biomedical Engineering
CiteScore
4.60
自引率
4.20%
发文量
226
审稿时长
11 weeks
期刊介绍: Journal of Functional Biomaterials (JFB, ISSN 2079-4983) is an international and interdisciplinary scientific journal that publishes regular research papers (articles), reviews and short communications about applications of materials for biomedical use. JFB covers subjects from chemistry, pharmacy, biology, physics over to engineering. The journal focuses on the preparation, performance and use of functional biomaterials in biomedical devices and their behaviour in physiological environments. Our aim is to encourage scientists to publish their results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Several topical special issues will be published. Scope: adhesion, adsorption, biocompatibility, biohybrid materials, bio-inert materials, biomaterials, biomedical devices, biomimetic materials, bone repair, cardiovascular devices, ceramics, composite materials, dental implants, dental materials, drug delivery systems, functional biopolymers, glasses, hyper branched polymers, molecularly imprinted polymers (MIPs), nanomedicine, nanoparticles, nanotechnology, natural materials, self-assembly smart materials, stimuli responsive materials, surface modification, tissue devices, tissue engineering, tissue-derived materials, urological devices.
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