比较接受传统疗法和支持性姑息治疗套餐的胃肠道癌症晚期患者的质量调整生命年(QALYs)。

IF 1.1 Q4 PRIMARY HEALTH CARE Journal of Family Medicine and Primary Care Pub Date : 2024-09-01 Epub Date: 2024-09-11 DOI:10.4103/jfmpc.jfmpc_2032_23
Samira Vaziri, Kourosh Javdani Esfehani, Reza Hamidi, Hassan Amiri, Mobin Naghshbandi, Mahdi Rezai, Fatemeh Mohammadi
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引用次数: 0

摘要

研究目的本研究旨在比较胃肠道癌症患者在接受姑息治疗和支持治疗后的质量调整生命年(QALYs):这项观察性研究在伊朗德黑兰的 Firoozgar 医院进行,包括 500 名终末期胃肠道癌症患者。研究将这些患者分为两组:250 人使用了姑息治疗服务,其余 250 人未使用。研究比较了两组患者的病情:在接受姑息治疗的患者中,只有 21% 接受了化疗,明显低于非姑息治疗组的 55%(P < 0.001)。姑息治疗组的住院死亡率大大降低,为115人(46%),而非姑息治疗组为200人(80%)(P < 0.001)。接受姑息治疗的患者平均住院时间为(25.11 ± 5.12)天,明显短于非姑息治疗组(96.42 ± 14.15)天(P < 0.001)。根据EuroQol 5-Dimensions 3-Levels (EQ-5D-3L)调查问卷的评分结果显示,姑息治疗组患者在疼痛和情绪症状方面的疗效明显优于非姑息治疗组,但在身体功能方面与非姑息治疗组相比无明显差异:结论:建议对胃肠道癌症患者采取姑息治疗,因为它可以大大减少不必要的转院和住院时间。
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Comparison of quality-adjusted life years (QALYs) of end-stage patients with gastrointestinal cancers receiving conventional therapies with recipients of supportive-palliative care package.

Objective: This study aimed to compare the quality-adjusted life years (QALYs) of patients with gastrointestinal (GI) cancer after receiving palliative and supportive care.

Materials and methods: Conducted at Firoozgar Hospital in Tehran, Iran, this observational study included 500 end-stage gastrointestinal cancer patients. The study divided these patients into two groups: 250 utilized palliative medicine services, while the remaining 250 did not. The study compared the conditions of patients in both groups.

Results: Among those receiving palliative care, only 21% underwent chemotherapy, significantly lower than the 55% in the non-palliative care group (P < 0.001). Hospital mortality rates were considerably reduced in the palliative care group, with 115 patients (46%) compared to 200 patients (80%) in the non-palliative group (P < 0.001). The average hospital stay for patients receiving palliative care was 25.11 ± 5.12 days, significantly shorter than the 96.42 ± 14.15 days in the non-palliative group (P < 0.001). The EuroQol 5-Dimensions 3-Levels (EQ-5D-3L) questionnaire scores showed that patients in the palliative care group experienced significantly better outcomes in pain and mood symptoms, but no significant difference was observed in physical function compared to the non-palliative group.

Conclusion: Palliative medicine is recommended for gastrointestinal cancer patients as it can significantly reduce unnecessary hospital referrals and length of hospitalization.

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