探索印度老年患者瘦素水平与代谢综合征之间的联系:对家庭医学和初级保健实践的启示。

IF 1.1 Q4 PRIMARY HEALTH CARE Journal of Family Medicine and Primary Care Pub Date : 2024-09-01 Epub Date: 2024-09-11 DOI:10.4103/jfmpc.jfmpc_2008_23
Arjun Kumar Singhal, Gaurav Singh, Shravan Kumar Singh, Busi Karunanand, Gagan Gunjan, Sonu K Agrawal
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引用次数: 0

摘要

背景:根据美国国家胆固醇教育计划成人治疗小组 III,代谢综合征(MetS)是一组代谢异常,包括以下特征中的一项、两项或全部三项:腹部肥胖、血脂异常、高血压、空腹血糖或胰岛素抵抗。本研究旨在评估印度北部人群中患有 T2DM 的老年人空腹血清瘦素与 MetS 之间的关系:收集了所有参与者的以下信息:(1) 人体测量数据;(2) 生化数据;(3) 关于社会人口学数据、饮食习惯、吸烟和酒精摄入量的生活方式问卷,以确定他们患糖尿病、心血管疾病和高血压的风险因素:共有 36 名老年参与者(56.30%)有高血压病史,29 名老年参与者(44.61%)有糖尿病。共有 32 名老年参与者(占 49.2%)患有 MetS,该群体的血清瘦素(P 0.003)、体重(P = 0.019)、体重指数(BMI)(P 0.001)、腰围(P 0.001)、CRP(P = 0.021)、胰岛素(P = 0.001)、胰岛素(P = 0.001)、HOMA-IR(P = 0.003)值以及女性(P = 0.001)、2 型糖尿病(P = 0.002)和高血压(P = 0.039)患者的比例均高于非 MetS 组:结论:在患有 T2DM 的老年人中,我们的研究发现血清瘦素与 MetS 之间存在良好的相关性。结论:我们的研究发现,在患有 T2DM 的老年人中,血清瘦素与 MetS 之间存在良好的相关性,它可以作为 MetS 的一个独立指标,为发现相关后果的高危人群提供一种方法,并能进行早期干预。
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Exploring the link between leptin levels and metabolic syndrome in elderly Indian patients: Implications for family medicine and primary care practices.

Background: The metabolic syndrome (MetS), according to the Adult Treatment Panel III of the National Cholesterol Education Programme, is a collection of metabolic abnormalities that includes one, two, or all three of the following traits: obesity in the abdomen, dyslipidemia, hypertension, fasting blood sugar, or insulin resistance. This study's aim was to assess the relationship between fasting serum leptin and MetS in elderly adults with T2DM in the Northern Indian population.

Material and methods: The following information was collected from all the participants: (1) anthropometric data, (2) biochemical data, and (3) a lifestyle questionnaire on sociodemographic data, dietary practices, smoking, and alcohol intake to identify their risk factors for diabetes mellitus, CVD, and hypertension.

Results: A total of 36 older participants (56.30%) had a history of hypertension, while 29 elderly participants (44.61%) had diabetes mellitus. A total of 32 elderly participants (49.2%) had MetS, and this group had higher serum leptin (P 0.003), body weight (P = 0.019), BMI (P 0.001), waist circumference (P 0.001), CRP (P = 0.021), insulin (P = 0.001), and HOMA-IR (P = 0.003) values as well as higher percentages of females (P = 0.001), and those with type 2 diabetes mellitus (P = 0.002) and hypertension (P = 0.039) than those in the non-MetS group.

Conclusion: In older persons with T2DM, our study discovered a favorable correlation between serum leptin and MetS. It can act as a standalone indicator of MetS, offering a way to spot populations at risk for associated consequences and enabling early intervention.

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