具有组织粘合、抗菌和血管生成功能的磷酸氢化铜纳米片功能化水凝胶用于气管粘膜再生。

IF 10.6 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Journal of Nanobiotechnology Pub Date : 2024-10-23 DOI:10.1186/s12951-024-02920-8
Pengli Wang, Erji Gao, Tao Wang, Yanping Feng, Yong Xu, Lefeng Su, Wei Gao, Zheng Ci, Muhammad Rizwan Younis, Jiang Chang, Chen Yang, Liang Duan
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引用次数: 0

摘要

在临床实践中,气管粘膜损伤后缺乏及时有效的干预措施,从而增加了气道感染、气管软骨退化甚至窒息死亡的风险。在此,我们提出了一种基于生物材料的气管粘膜损伤修复策略,其基础是磷酸氢化铜纳米片(CuHP NSs)功能化商用水凝胶(聚乙二醇二琥珀酰亚胺-人血清白蛋白,PH)。这种 CuHP/PH 水凝胶在气管腔内具有良好的注射性、稳定的凝胶化和出色的粘附性。此外,CuHP/PH 水凝胶中的 CuHP NSs 能有效刺激内皮/上皮细胞的增殖和迁移,促进血管生成,显示出卓越的组织再生潜力。此外,它还对细菌和细菌生物膜有明显的抑制作用。更重要的是,在纤维支气管镜引导下,将 CuHP/PH 水凝胶注入气管粘膜损伤部位,结果表明 CuHP/PH 水凝胶与气管粘膜紧密粘合。CuHP/PH 水凝胶的治疗效果得到了进一步证实,其显著提高了存活率、血管和粘膜再生能力,减少了腔内感染、气管狭窄和软骨损伤等并发症的发生。这项研究提出了一个初步主张,概述了采用生物材料减轻气管粘膜损伤的策略,为治疗粘膜损伤和其他气管疾病提供了新的视角。
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Copper hydrogen phosphate nanosheets functionalized hydrogel with tissue adhesive, antibacterial, and angiogenic capabilities for tracheal mucosal regeneration.

Timely and effective interventions after tracheal mucosal injury are lack in clinical practices, which elevate the risks of airway infection, tracheal cartilage deterioration, and even asphyxiated death. Herein, we proposed a biomaterial-based strategy for the repair of injured tracheal mucosal based on a copper hydrogen phosphate nanosheets (CuHP NSs) functionalized commercial hydrogel (polyethylene glycol disuccinimidyl succinate-human serum albumin, PH). Such CuHP/PH hydrogel achieved favorable injectability, stable gelation, and excellent adhesiveness within the tracheal lumen. Moreover, CuHP NSs within the CuHP/PH hydrogel effectively stimulate the proliferation and migration of endothelial/epithelial cells, enhancing angiogenesis and demonstrating excellent tissue regenerative potential. Additionally, it exhibited significant inhibitory effects on both bacteria and bacterial biofilms. More importantly, when injected injured site of tracheal mucosa under fiberoptic bronchoscopy guidance, our results demonstrated CuHP/PH hydrogel adhered tightly to the tracheal mucosa. The therapeutic effects of the CuHP/PH hydrogel were further confirmed, which significantly improved survival rates, vascular and mucosal regeneration, reduced occurrences of intraluminal infections, tracheal stenosis, and cartilage damage complications. This research presents an initial proposition outlining a strategy employing biomaterials to mitigate tracheal mucosal injury, offering novel perspectives on the treatment of mucosal injuries and other tracheal diseases.

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来源期刊
Journal of Nanobiotechnology
Journal of Nanobiotechnology BIOTECHNOLOGY & APPLIED MICROBIOLOGY-NANOSCIENCE & NANOTECHNOLOGY
CiteScore
13.90
自引率
4.90%
发文量
493
审稿时长
16 weeks
期刊介绍: Journal of Nanobiotechnology is an open access peer-reviewed journal communicating scientific and technological advances in the fields of medicine and biology, with an emphasis in their interface with nanoscale sciences. The journal provides biomedical scientists and the international biotechnology business community with the latest developments in the growing field of Nanobiotechnology.
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