Xingze Liu , Xiang Wang , Jie Fan , Qian Liu , Chuman Xiao , Feng Gao , Jie Xia , Yan Han , Xiongzhao Zhu , Haiyan Liao
{"title":"下顶叶皮层和球状苍白球对家庭冲突与重度抑郁障碍之间关系的中介效应。","authors":"Xingze Liu , Xiang Wang , Jie Fan , Qian Liu , Chuman Xiao , Feng Gao , Jie Xia , Yan Han , Xiongzhao Zhu , Haiyan Liao","doi":"10.1016/j.jpsychires.2024.10.014","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>Family conflict is an important risk factor for major depressive disorder (MDD) and is associated with structural alterations in the brain. However, it is unclear whether structural alterations associated with family conflict would contribute to depression. This study aims to investigate the neuroimaging characteristics that connect family conflict with depression.</div></div><div><h3>Methods</h3><div>This study included 54 healthy controls and 53 antidepressant-free patients with MDD. Both groups completed the Beck Depression Inventory-II, the simplified Chinese version of the Family Environment Scale, and the Childhood Trauma Questionnaire. Structural Magnetic Resonance Imaging data was collected to measure cortical thickness and regional gray matter volumes.</div></div><div><h3>Results</h3><div>Family conflict has a significant effect on depression diagnosis. Higher levels of family conflict were positively associated with symptoms of <em>sadness</em>, <em>guilty feelings</em>, and <em>punishment feelings</em> in patients, as well as with cortical thickness in the right inferior-parietal cluster and the volumes of the left globus pallidus in all participants. In the patient group, cortical thickness in the right inferior-parietal cluster and volume of the left globus pallidus were negatively related to symptoms of <em>sadness</em> and <em>guilty feelings,</em> respectively. The structural alteration in the right inferior-parietal cluster mediated the relationship of family conflict and <em>sadness</em>, whereas changes in the globus pallidus mediated the associations between family conflict and both depression and <em>guilty feelings</em> in patients.</div></div><div><h3>Conclusion</h3><div>Findings revealed the relationships between family conflict and depression, including both depression diagnosis and specific symptoms. Cortical thickness in the right inferior-parietal cortex and the volume of the left globus pallidus played mediating roles in these relationships, indicating the important contributions of these brain regions to the effect of family conflict on depression.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"180 ","pages":"Pages 219-226"},"PeriodicalIF":3.7000,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The mediation effect of the inferior-parietal cortex and globus pallidus on the relationship between family conflict and major depressive disorder\",\"authors\":\"Xingze Liu , Xiang Wang , Jie Fan , Qian Liu , Chuman Xiao , Feng Gao , Jie Xia , Yan Han , Xiongzhao Zhu , Haiyan Liao\",\"doi\":\"10.1016/j.jpsychires.2024.10.014\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div>Family conflict is an important risk factor for major depressive disorder (MDD) and is associated with structural alterations in the brain. However, it is unclear whether structural alterations associated with family conflict would contribute to depression. This study aims to investigate the neuroimaging characteristics that connect family conflict with depression.</div></div><div><h3>Methods</h3><div>This study included 54 healthy controls and 53 antidepressant-free patients with MDD. Both groups completed the Beck Depression Inventory-II, the simplified Chinese version of the Family Environment Scale, and the Childhood Trauma Questionnaire. Structural Magnetic Resonance Imaging data was collected to measure cortical thickness and regional gray matter volumes.</div></div><div><h3>Results</h3><div>Family conflict has a significant effect on depression diagnosis. Higher levels of family conflict were positively associated with symptoms of <em>sadness</em>, <em>guilty feelings</em>, and <em>punishment feelings</em> in patients, as well as with cortical thickness in the right inferior-parietal cluster and the volumes of the left globus pallidus in all participants. In the patient group, cortical thickness in the right inferior-parietal cluster and volume of the left globus pallidus were negatively related to symptoms of <em>sadness</em> and <em>guilty feelings,</em> respectively. The structural alteration in the right inferior-parietal cluster mediated the relationship of family conflict and <em>sadness</em>, whereas changes in the globus pallidus mediated the associations between family conflict and both depression and <em>guilty feelings</em> in patients.</div></div><div><h3>Conclusion</h3><div>Findings revealed the relationships between family conflict and depression, including both depression diagnosis and specific symptoms. Cortical thickness in the right inferior-parietal cortex and the volume of the left globus pallidus played mediating roles in these relationships, indicating the important contributions of these brain regions to the effect of family conflict on depression.</div></div>\",\"PeriodicalId\":16868,\"journal\":{\"name\":\"Journal of psychiatric research\",\"volume\":\"180 \",\"pages\":\"Pages 219-226\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2024-10-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of psychiatric research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0022395624005909\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of psychiatric research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0022395624005909","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
The mediation effect of the inferior-parietal cortex and globus pallidus on the relationship between family conflict and major depressive disorder
Objective
Family conflict is an important risk factor for major depressive disorder (MDD) and is associated with structural alterations in the brain. However, it is unclear whether structural alterations associated with family conflict would contribute to depression. This study aims to investigate the neuroimaging characteristics that connect family conflict with depression.
Methods
This study included 54 healthy controls and 53 antidepressant-free patients with MDD. Both groups completed the Beck Depression Inventory-II, the simplified Chinese version of the Family Environment Scale, and the Childhood Trauma Questionnaire. Structural Magnetic Resonance Imaging data was collected to measure cortical thickness and regional gray matter volumes.
Results
Family conflict has a significant effect on depression diagnosis. Higher levels of family conflict were positively associated with symptoms of sadness, guilty feelings, and punishment feelings in patients, as well as with cortical thickness in the right inferior-parietal cluster and the volumes of the left globus pallidus in all participants. In the patient group, cortical thickness in the right inferior-parietal cluster and volume of the left globus pallidus were negatively related to symptoms of sadness and guilty feelings, respectively. The structural alteration in the right inferior-parietal cluster mediated the relationship of family conflict and sadness, whereas changes in the globus pallidus mediated the associations between family conflict and both depression and guilty feelings in patients.
Conclusion
Findings revealed the relationships between family conflict and depression, including both depression diagnosis and specific symptoms. Cortical thickness in the right inferior-parietal cortex and the volume of the left globus pallidus played mediating roles in these relationships, indicating the important contributions of these brain regions to the effect of family conflict on depression.
期刊介绍：
Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research:
(1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors;
(2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology;
(3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;
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