微藻酚类物质:以方法评估和元分析为重点的系统性综述。

IF 4.9 2区 医学 Q1 CHEMISTRY, MEDICINAL Marine Drugs Pub Date : 2024-10-07 DOI:10.3390/md22100460
Vasilis Andriopoulos, Michael Kornaros
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引用次数: 0

摘要

我们对有关真核微藻酚含量的文献进行了严格的审查和分析。发现并讨论了几个问题。总之,有关微藻类酚含量报告的主要问题如下:(1) 尽管 Folin-Ciocalteu 法可用于测定植物样本中的酚含量,但由于微藻提取物中存在大量干扰化合物,如有机提取物中的叶绿素及其衍生物和水提取物中的游离芳香族氨基酸或核苷酸,因此该方法不适用于微藻研究;(2) 虽然有色谱证据表明大多数微藻支系中存在简单的酚酸,但由于大多数微藻中缺乏酚类生物合成的关键酶,而且即使在同一属中,酚类概况的变异性也很大,因此在得出结论之前需要进行更广泛的研究;(3) 在关注微藻酚类含量的研究中,几乎普遍忽视了微藻外部酚类的积累和代谢,即使在培养过程中使用天然海水或复杂的有机培养基也是如此。尽管存在这些问题,但通过微藻对富含酚类物质的废水进行生物修复的文献表明,这些生物有能力吸附、内化和在许多情况下氧化或转化各种酚类化合物,即使浓度非常高。在橄榄油厂废料等废物流中发现的简单酚类化合物已被证明能增强微藻提取物的抗氧化活性和各种生物活性,而酚类化合物的复杂生物转化产物也已被证实。总之,通过真核微藻从头开始生物合成酚类化合物需要通过设计更好的实验和合适的分析方法进行进一步研究,而微藻对其生长介质中酚类化合物的反应则具有极大的实际意义,无论是在废物处理方面,还是在生产功能性食品、化妆品和药品方面。
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Microalgal Phenolics: Systematic Review with a Focus on Methodological Assessment and Meta-Analysis.

A critical review and analysis of the literature relevant to the phenolic content of eucaryotic microalgae was performed. Several issues were identified and discussed. In summary, the main problems with the reporting on the phenolic content of microalgae are the following: (1) despite its usefulness in the determination of phenolic content in plant samples, the Folin-Ciocalteu assay is non-suitable for microalgal research due to the high presence of interfering compounds in microalgal extracts such as chlorophyll and its derivatives in organic extracts and free aromatic amino acids or nucleotides in aqueous extracts; (2) while there is chromatographic evidence for the presence of simple phenolic acids in most microalgal clades, the lack of critical enzymes of phenolic biosynthesis in most microalgae, as well as the high variability of phenolic profiles even in the same genus, require more extensive research before conclusions are drawn; (3) the accumulation and metabolism of external phenolics by microalgae has been almost universally neglected in studies focusing on the phenolic content of microalgae, even when natural seawater or complex organic media are used in the cultivation process. Despite these issues, the literature focusing on the bioremediation of waste streams rich in phenolics through microalgae demonstrates the ability of those organisms to adsorb, internalize, and in many cases oxidize or transform a wide range of phenolic compounds, even at very high concentrations. Simple phenolics found in waste streams, such as olive mill waste, have been shown to enhance the antioxidant activity and various bioactivities of microalgal extracts, while complex biotransformation products of phenolics have also been characterized. In conclusion, the de novo biosynthesis of phenolic compounds via eucaryotic microalgae requires further investigation with better designed experiments and suitable analytical methods, while the response of microalgae to phenolic compounds in their growth medium is of great practical interest, both in terms of waste treatment and for the production of functional foods, cosmetics, and pharmaceuticals.

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来源期刊
Marine Drugs
Marine Drugs 医学-医药化学
CiteScore
9.60
自引率
14.80%
发文量
671
审稿时长
1 months
期刊介绍: Marine Drugs (ISSN 1660-3397) publishes reviews, regular research papers and short notes on the research, development and production of drugs from the sea. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible, particularly synthetic procedures and characterization information for bioactive compounds. There is no restriction on the length of the experimental section.
期刊最新文献
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