综述石墨烯基纳米材料在应对 COVID-19 大流行带来的挑战中的作用。

IF 3.3 3区 医学 Q3 IMMUNOLOGY Microbial pathogenesis Pub Date : 2024-10-22 DOI:10.1016/j.micpath.2024.107059
Sachin Sharma Ashok Kumar , Shahid Bashir , M. Pershaanaa , Fathiah Kamarulazam , A.V. Kuppusamy , Nujud Badawi , K. Ramesh , S. Ramesh
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引用次数: 0

摘要

2020 年,由于严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)导致冠状病毒病(COVID-19)的出现,世界卫生组织(WHO)宣布该病为大流行病。目前,许多新变种和变异株的出现被认为比以前的毒株危害更大。因此,世界各地的科研人员都在努力研究 COVID-19 的发病机制、原因、传播途径以及治疗方法。然而,尽管取得了一些研究成果,但仍有许多未知因素有待探索。因此,在取得这些进展的同时,还必须设计出有效的系统,结合智能材料来对抗 COVID-19。因此,人们采用了多种方法来对抗 COVID-19。最近,石墨烯基材料因其优越的物理化学特性,为高灵敏度和高选择性的光学、电化学传感和诊断应用提供了高效的纳米平台,因此已被探索用于应对当前的 COVID-19 和未来的流行病。此外,基于光热效应或活性氧的形成,碳基纳米材料在靶向抗病毒给药和抑制致病病毒方面也显示出了潜力。因此,这篇综述文章揭示了与石墨烯和相关材料有关的最新进展和最有前景的策略,以及其在检测、净化、诊断和防护 COVID-19 方面的应用。此外,文章还详细讨论了基于石墨烯材料的技术的基础设计和开发所面临的主要挑战和未来方向,以及石墨烯产品的需求方面,最后还就改进这些技术的适当方法分别提出了我们的个人观点。
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A review of the role of graphene-based nanomaterials in tackling challenges posed by the COVID-19 pandemic
In 2020, the World Health Organization (WHO) declared a pandemic due to the emergence of the coronavirus disease (COVID-19) which had resulted by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). At present, the emergence of many new variants and mutants were found to be more harmful compared to the previous strains. As a result, research scientists around the world had devoted significant efforts to understand the mechanism, causes and transmission due to COVID-19 along with the treatment to cure these diseases. However, despite achieving several findings, much more was unknown and yet to be explored. Hence, along with these developments, it is also extremely essential to design effective systems by incorporating smart materials to battle the COVID-19. Therefore, several approaches have been implemented to combat against COVID-19. Recently, the graphene-based materials have been explored for the current COVID-19 and future pandemics due to its superior physicochemical properties, providing efficient nanoplatforms for optical and electrochemical sensing and diagnostic applications with high sensitivity and selectivity. Moreover, based on the photothermal effects or reactive oxygen species formation, the carbon-based nanomaterials have shown its potentiality for targeted antiviral drug delivery and the inhibitory effects against pathogenic viruses. Therefore, this review article sheds light on the recent progress and the most promising strategies related to graphene and related materials and its applications for detection, decontamination, diagnosis, and protection against COVID-19. In addition, the key challenges and future directives are discussed in detail for fundamental design and development of technologies based on graphene-based materials along with the demand aspects of graphene-based products and lastly, our personal opinions on the appropriate approaches to improve these technologies respectively.
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来源期刊
Microbial pathogenesis
Microbial pathogenesis 医学-免疫学
CiteScore
7.40
自引率
2.60%
发文量
472
审稿时长
56 days
期刊介绍: Microbial Pathogenesis publishes original contributions and reviews about the molecular and cellular mechanisms of infectious diseases. It covers microbiology, host-pathogen interaction and immunology related to infectious agents, including bacteria, fungi, viruses and protozoa. It also accepts papers in the field of clinical microbiology, with the exception of case reports. Research Areas Include: -Pathogenesis -Virulence factors -Host susceptibility or resistance -Immune mechanisms -Identification, cloning and sequencing of relevant genes -Genetic studies -Viruses, prokaryotic organisms and protozoa -Microbiota -Systems biology related to infectious diseases -Targets for vaccine design (pre-clinical studies)
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