lncRNAs 在调控癌症治疗中的治疗潜力

IF 2.9 4区 医学 Q2 PATHOLOGY Pathology, research and practice Pub Date : 2024-10-16 DOI:10.1016/j.prp.2024.155657
Abida , Abdulmalik S.A. Altamimi , Nehmat Ghaboura , Ashok Kumar Balaraman , Pranchal Rajput , Pooja Bansal , Sushama Rawat , Fadiyah Jadid Alanazi , Abeer Nuwayfi Alruwaili , Nouf Afit Aldhafeeri , Haider Ali , Pran Kishore Deb
{"title":"lncRNAs 在调控癌症治疗中的治疗潜力","authors":"Abida ,&nbsp;Abdulmalik S.A. Altamimi ,&nbsp;Nehmat Ghaboura ,&nbsp;Ashok Kumar Balaraman ,&nbsp;Pranchal Rajput ,&nbsp;Pooja Bansal ,&nbsp;Sushama Rawat ,&nbsp;Fadiyah Jadid Alanazi ,&nbsp;Abeer Nuwayfi Alruwaili ,&nbsp;Nouf Afit Aldhafeeri ,&nbsp;Haider Ali ,&nbsp;Pran Kishore Deb","doi":"10.1016/j.prp.2024.155657","DOIUrl":null,"url":null,"abstract":"<div><div>Non-coding RNAs (lncRNAs) play critical roles in various cellular processes, including a novel form of regulated cell death known as disulfidptosis, characterized by accumulating protein disulfide bonds and severe endoplasmic reticulum stress. This review highlights the therapeutic potential of lncRNAs in regulating disulfidptosis for cancer treatment, emphasizing their influence on key pathway components such as GPX4, SLC7A11, and PDIA family members. Recent studies have demonstrated that targeting specific lncRNAs can sensitize cancer cells to disulfidptosis, offering a promising approach to cancer therapy. The regulation of disulfidptosis by lncRNAs involves various signaling pathways, including oxidative stress, ER stress, and calcium signaling. This review also discusses the molecular mechanisms underlying lncRNA regulation of disulfidptosis, the challenges of developing lncRNA-based therapies, and the future potential of this rapidly advancing field in cancer research.</div></div>","PeriodicalId":19916,"journal":{"name":"Pathology, research and practice","volume":"263 ","pages":"Article 155657"},"PeriodicalIF":2.9000,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Therapeutic Potential of lncRNAs in Regulating Disulfidptosis for Cancer Treatment\",\"authors\":\"Abida ,&nbsp;Abdulmalik S.A. Altamimi ,&nbsp;Nehmat Ghaboura ,&nbsp;Ashok Kumar Balaraman ,&nbsp;Pranchal Rajput ,&nbsp;Pooja Bansal ,&nbsp;Sushama Rawat ,&nbsp;Fadiyah Jadid Alanazi ,&nbsp;Abeer Nuwayfi Alruwaili ,&nbsp;Nouf Afit Aldhafeeri ,&nbsp;Haider Ali ,&nbsp;Pran Kishore Deb\",\"doi\":\"10.1016/j.prp.2024.155657\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Non-coding RNAs (lncRNAs) play critical roles in various cellular processes, including a novel form of regulated cell death known as disulfidptosis, characterized by accumulating protein disulfide bonds and severe endoplasmic reticulum stress. This review highlights the therapeutic potential of lncRNAs in regulating disulfidptosis for cancer treatment, emphasizing their influence on key pathway components such as GPX4, SLC7A11, and PDIA family members. Recent studies have demonstrated that targeting specific lncRNAs can sensitize cancer cells to disulfidptosis, offering a promising approach to cancer therapy. The regulation of disulfidptosis by lncRNAs involves various signaling pathways, including oxidative stress, ER stress, and calcium signaling. This review also discusses the molecular mechanisms underlying lncRNA regulation of disulfidptosis, the challenges of developing lncRNA-based therapies, and the future potential of this rapidly advancing field in cancer research.</div></div>\",\"PeriodicalId\":19916,\"journal\":{\"name\":\"Pathology, research and practice\",\"volume\":\"263 \",\"pages\":\"Article 155657\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2024-10-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pathology, research and practice\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0344033824005685\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PATHOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pathology, research and practice","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0344033824005685","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PATHOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

非编码RNA(lncRNA)在各种细胞过程中发挥着关键作用,其中包括一种新型的细胞死亡调控形式,即二硫化血症,其特点是蛋白质二硫键累积和严重的内质网应激。本综述强调了lncRNAs在调控二硫化硫过程中对癌症治疗的潜力,强调了它们对GPX4、SLC7A11和PDIA家族成员等关键通路成分的影响。最近的研究表明,靶向特定的 lncRNA 可使癌细胞对二硫化硫敏感,为癌症治疗提供了一种前景广阔的方法。lncRNAs对二硫化硫的调控涉及多种信号通路,包括氧化应激、ER应激和钙信号转导。这篇综述还讨论了lncRNA调控二硫化硫的分子机制、开发基于lncRNA的疗法所面临的挑战以及这一快速发展的癌症研究领域的未来潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Therapeutic Potential of lncRNAs in Regulating Disulfidptosis for Cancer Treatment
Non-coding RNAs (lncRNAs) play critical roles in various cellular processes, including a novel form of regulated cell death known as disulfidptosis, characterized by accumulating protein disulfide bonds and severe endoplasmic reticulum stress. This review highlights the therapeutic potential of lncRNAs in regulating disulfidptosis for cancer treatment, emphasizing their influence on key pathway components such as GPX4, SLC7A11, and PDIA family members. Recent studies have demonstrated that targeting specific lncRNAs can sensitize cancer cells to disulfidptosis, offering a promising approach to cancer therapy. The regulation of disulfidptosis by lncRNAs involves various signaling pathways, including oxidative stress, ER stress, and calcium signaling. This review also discusses the molecular mechanisms underlying lncRNA regulation of disulfidptosis, the challenges of developing lncRNA-based therapies, and the future potential of this rapidly advancing field in cancer research.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
5.00
自引率
3.60%
发文量
405
审稿时长
24 days
期刊介绍: Pathology, Research and Practice provides accessible coverage of the most recent developments across the entire field of pathology: Reviews focus on recent progress in pathology, while Comments look at interesting current problems and at hypotheses for future developments in pathology. Original Papers present novel findings on all aspects of general, anatomic and molecular pathology. Rapid Communications inform readers on preliminary findings that may be relevant for further studies and need to be communicated quickly. Teaching Cases look at new aspects or special diagnostic problems of diseases and at case reports relevant for the pathologist''s practice.
期刊最新文献
The prognostic value of histological grade determined after neoadjuvant chemotherapy of breast cancer The phenotype of necrotizing enterocolitis correlates with distinct changes of intestinal junctional proteins Whole genome profiling of rare pediatric thoracic tumors elucidates a YAP1::LEUTX fusion in an unclassified biphasic embryonal neoplasm Comparison of three specimen collection techniques in tissue coagulum clot-based cell block preparation of endobronchial ultrasound-guided transbronchial needle aspiration Direct and indirect modulation of STAT3/CSE/H2S axis in triple negative breast cancer by non-coding RNAs: MALAT-1 lncRNA, miR-486–5p and miR-30a-5p
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1