Robin Straathof, Sharline M van Vliet-Pérez, Inger-Karine K Kolkman-Deurloo, Linda S G L Wauben, Remi A Nout, Ben J M Heijmen, Linda Rossi, Jenny Dankelman, Nick J van de Berg
{"title":"自动规划用于宫颈癌近距离治疗的 3D 打印患者定制涂抹器中的弯曲针道。","authors":"Robin Straathof, Sharline M van Vliet-Pérez, Inger-Karine K Kolkman-Deurloo, Linda S G L Wauben, Remi A Nout, Ben J M Heijmen, Linda Rossi, Jenny Dankelman, Nick J van de Berg","doi":"10.1088/1361-6560/ad8b08","DOIUrl":null,"url":null,"abstract":"<p><p><i>Purpose.</i>Patient-tailored intracavitary/interstitial (IC/IS) brachytherapy (BT) applicators may increase dose conformity in cervical cancer patients. Current configuration planning methods in these custom applicators rely on manual specification or a small set of (straight) needles. This work introduces and validates a two-stage approach for establishing channel configurations in the 3D printed patient-tailored ARCHITECT applicator.<i>Methods.</i>For each patient, the patient-tailored applicator shape was based on the first BT application with a commercial applicator and integrated connectors to a commercial (Geneva) intrauterine tube and two lunar ring channels. First, a large candidate set was generated of channels that steer the needle to desired poses in the target region and are contained in the applicator. The channels' centrelines were represented by Bézier curves. Channels running between straight target segments and entry points were optimised and refined to ensure (dynamic) feasibility. Second, channel configurations were selected using geometric coverage optimisation. This workflow was applied to establish patient-tailored geometries for twenty-two patients previously treated using the Venezia applicator. Treatment plans were automatically generated using the in-house developed algorithm BiCycle. Plans for the clinically used configuration,TPclin, and patient-tailored configuration,TParch, were compared.<i>Results.</i>Channel configurations could be generated in clinically feasible time (median: 2651 s, range 1826-3812 s). AllTParchandTPclinplans were acceptable, but planning aims were more frequently attained with patient-tailored configurations (115/132 versus 100/132 instances). Median CTV<sub>IR</sub>D98and bladderD2cm3doses significantly improved (p<0.001 andp<0.01 respectively) inTParchplans in comparison withTPclinplans, and in approximately half of the patients dosimetric indices improved.<i>Conclusion.</i>Automated patient-tailored BT channel configuration planning for 3D printed applicators is clinically feasible. A treatment planning study showed that all plans met planning limits for the patient-tailored configurations, and in selected cases improved the plan quality in comparison with commercial applicator configurations.</p>","PeriodicalId":20185,"journal":{"name":"Physics in medicine and biology","volume":" ","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Automated planning of curved needle channels in 3D printed patient-tailored applicators for cervical cancer brachytherapy.\",\"authors\":\"Robin Straathof, Sharline M van Vliet-Pérez, Inger-Karine K Kolkman-Deurloo, Linda S G L Wauben, Remi A Nout, Ben J M Heijmen, Linda Rossi, Jenny Dankelman, Nick J van de Berg\",\"doi\":\"10.1088/1361-6560/ad8b08\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Purpose.</i>Patient-tailored intracavitary/interstitial (IC/IS) brachytherapy (BT) applicators may increase dose conformity in cervical cancer patients. Current configuration planning methods in these custom applicators rely on manual specification or a small set of (straight) needles. This work introduces and validates a two-stage approach for establishing channel configurations in the 3D printed patient-tailored ARCHITECT applicator.<i>Methods.</i>For each patient, the patient-tailored applicator shape was based on the first BT application with a commercial applicator and integrated connectors to a commercial (Geneva) intrauterine tube and two lunar ring channels. First, a large candidate set was generated of channels that steer the needle to desired poses in the target region and are contained in the applicator. The channels' centrelines were represented by Bézier curves. Channels running between straight target segments and entry points were optimised and refined to ensure (dynamic) feasibility. Second, channel configurations were selected using geometric coverage optimisation. This workflow was applied to establish patient-tailored geometries for twenty-two patients previously treated using the Venezia applicator. Treatment plans were automatically generated using the in-house developed algorithm BiCycle. Plans for the clinically used configuration,TPclin, and patient-tailored configuration,TParch, were compared.<i>Results.</i>Channel configurations could be generated in clinically feasible time (median: 2651 s, range 1826-3812 s). AllTParchandTPclinplans were acceptable, but planning aims were more frequently attained with patient-tailored configurations (115/132 versus 100/132 instances). Median CTV<sub>IR</sub>D98and bladderD2cm3doses significantly improved (p<0.001 andp<0.01 respectively) inTParchplans in comparison withTPclinplans, and in approximately half of the patients dosimetric indices improved.<i>Conclusion.</i>Automated patient-tailored BT channel configuration planning for 3D printed applicators is clinically feasible. A treatment planning study showed that all plans met planning limits for the patient-tailored configurations, and in selected cases improved the plan quality in comparison with commercial applicator configurations.</p>\",\"PeriodicalId\":20185,\"journal\":{\"name\":\"Physics in medicine and biology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-11-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Physics in medicine and biology\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1088/1361-6560/ad8b08\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physics in medicine and biology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1088/1361-6560/ad8b08","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
Automated planning of curved needle channels in 3D printed patient-tailored applicators for cervical cancer brachytherapy.
Purpose.Patient-tailored intracavitary/interstitial (IC/IS) brachytherapy (BT) applicators may increase dose conformity in cervical cancer patients. Current configuration planning methods in these custom applicators rely on manual specification or a small set of (straight) needles. This work introduces and validates a two-stage approach for establishing channel configurations in the 3D printed patient-tailored ARCHITECT applicator.Methods.For each patient, the patient-tailored applicator shape was based on the first BT application with a commercial applicator and integrated connectors to a commercial (Geneva) intrauterine tube and two lunar ring channels. First, a large candidate set was generated of channels that steer the needle to desired poses in the target region and are contained in the applicator. The channels' centrelines were represented by Bézier curves. Channels running between straight target segments and entry points were optimised and refined to ensure (dynamic) feasibility. Second, channel configurations were selected using geometric coverage optimisation. This workflow was applied to establish patient-tailored geometries for twenty-two patients previously treated using the Venezia applicator. Treatment plans were automatically generated using the in-house developed algorithm BiCycle. Plans for the clinically used configuration,TPclin, and patient-tailored configuration,TParch, were compared.Results.Channel configurations could be generated in clinically feasible time (median: 2651 s, range 1826-3812 s). AllTParchandTPclinplans were acceptable, but planning aims were more frequently attained with patient-tailored configurations (115/132 versus 100/132 instances). Median CTVIRD98and bladderD2cm3doses significantly improved (p<0.001 andp<0.01 respectively) inTParchplans in comparison withTPclinplans, and in approximately half of the patients dosimetric indices improved.Conclusion.Automated patient-tailored BT channel configuration planning for 3D printed applicators is clinically feasible. A treatment planning study showed that all plans met planning limits for the patient-tailored configurations, and in selected cases improved the plan quality in comparison with commercial applicator configurations.
期刊介绍:
The development and application of theoretical, computational and experimental physics to medicine, physiology and biology. Topics covered are: therapy physics (including ionizing and non-ionizing radiation); biomedical imaging (e.g. x-ray, magnetic resonance, ultrasound, optical and nuclear imaging); image-guided interventions; image reconstruction and analysis (including kinetic modelling); artificial intelligence in biomedical physics and analysis; nanoparticles in imaging and therapy; radiobiology; radiation protection and patient dose monitoring; radiation dosimetry