治疗胰腺癌的放射性药物：当前方法和未来方向综述》。

IF 4.3 3区医学 Q2 CHEMISTRY, MEDICINAL Pharmaceuticals Pub Date : 2024-10-01 DOI:10.3390/ph17101314

Sara Calistri, Giuseppe Ottaviano, Alberto Ubaldini

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引用次数: 0

摘要

胰腺癌预后不良，需要新的治疗方案。本综述探讨了放射性药物在胰腺癌治疗中的发展。与传统治疗方法相比，肽受体放射性核素治疗（PRRT）等成熟策略可提供靶向和有效的治疗。然而，目前欧洲还没有批准用于治疗胰腺癌的放射性药物，这就需要进一步的研究和新方法。包括放射性标记抗体、肽和纳米技术方法在内的新型放射性药物有望应对胰腺癌治疗的挑战。与传统疗法相比，这些新药物可能具有更强的特异性靶向性，并有可能提高疗效。要优化疗效、解决局限性并探索这些新策略在治疗这种侵袭性和有害病理方面的整体潜力，还需要进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Radiopharmaceuticals for Pancreatic Cancer: A Review of Current Approaches and Future Directions.

The poor prognosis of pancreatic cancer requires novel treatment options. This review examines the evolution of radiopharmaceuticals in the treatment of pancreatic cancer. Established strategies such as peptide receptor radionuclide therapy (PRRT) offer targeted and effective treatment, compared to conventional treatments. However, there are currently no radiopharmaceuticals approved for the treatment of pancreatic cancer in Europe, which requires further research and novel approaches. New radiopharmaceuticals including radiolabeled antibodies, peptides, and nanotechnological approaches are promising in addressing the challenges of pancreatic cancer therapy. These new agents may offer more specific targeting and potentially improve efficacy compared to traditional therapies. Further research is needed to optimize efficacy, address limitations, and explore the overall potential of these new strategies in the treatment of this aggressive and harmful pathology.

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来源期刊

Pharmaceuticals Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

6.10

自引率

4.30%

发文量

1332

审稿时长

6 weeks

期刊介绍： Pharmaceuticals (ISSN 1424-8247) is an international scientific journal of medicinal chemistry and related drug sciences.Our aim is to publish updated reviews as well as research articles with comprehensive theoretical and experimental details. Short communications are also accepted; therefore, there is no restriction on the maximum length of the papers.