Erman Ceyhan , Mehmet Vehbi Kayra , Eylem Gul Ates , Yalcın Kizilkan , Mesut Altan , Omer Yildirim , Mehmet Hamza Gultekin , Nebil Akdogan , Eray Hasirci , Tufan Cicek , Iyimser Ure , Cem Sah , Aykut Baser , Umit Gul , Hamdi Ozkara , Kadir Emre Akkus , Tahsin Turunc , Andrology Working Group of the Society of Urological Surgery in Turkey
{"title":"预测非梗阻性无精子症男性睾丸取精成功率的提名图:一项多中心研究。","authors":"Erman Ceyhan , Mehmet Vehbi Kayra , Eylem Gul Ates , Yalcın Kizilkan , Mesut Altan , Omer Yildirim , Mehmet Hamza Gultekin , Nebil Akdogan , Eray Hasirci , Tufan Cicek , Iyimser Ure , Cem Sah , Aykut Baser , Umit Gul , Hamdi Ozkara , Kadir Emre Akkus , Tahsin Turunc , Andrology Working Group of the Society of Urological Surgery in Turkey","doi":"10.1016/j.urology.2024.10.038","DOIUrl":null,"url":null,"abstract":"<div><h3>OBJECTIVE</h3><div>To develop an efficient and easy-to-use nomogram that can predict testicular sperm extraction (TESE) success in men with non-obstructive azoospermia (NOA) by using pre-operative parameters.</div></div><div><h3>MATERIALS AND METHODS</h3><div>Data of 3093 men who underwent TESE for NOA were included in this study. Demographic data, testis volumes, presence of varicocele, length of infertility, history of previous surgeries, history of genitourinary infections, smoking status, chromosome abnormalities, presence of Y-chromosome microdeletion, family history of infertility, testis biopsy, surgical data, sperm retrieval rate, final pathology obtained at TESE, follicle-stimulating hormone, luteinizing hormone, and testosterone levels were recorded. The primary outcome was to develop an efficient nomogram that can predict the TESE success in men with NOA. The secondary outcomes were identifying the significant pre-operative parameters that are associated with success in TESE.</div></div><div><h3>RESULTS</h3><div>Sperm retrieval rate was 50.2%(1553/3093). Testis volume, history of varicocelectomy, chromosome abnormalities, and presence of Y-chromosome microdeletion were shown to affect sperm retrieval rate significantly (<em>P</em> <.05). Sperm retrieval success was higher in men with older age, higher testis volume (>10 mL), lower follicle-stimulating hormone level (≤12.92 mIU/mL), lower luteinizing hormone level, and higher testosterone level (<em>P</em> <.05). Only testis volume and patient’s age were associated with successful sperm retrieval in multivariate logistic regression analysis.</div></div><div><h3>CONCLUSION</h3><div>In men with NOA, high testis volume, old age, low follicle-stimulating hormone level, low luteinizing hormone level, and high testosterone level are advantageous for successful sperm retrieval in TESE. Herein, we present a nomogram that can predict the outcome of TESE in men with NOA with adequate success.</div></div>","PeriodicalId":23415,"journal":{"name":"Urology","volume":"196 ","pages":"Pages 155-161"},"PeriodicalIF":2.1000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Nomogram Predicting Testicular Sperm Extraction Success in Men With Non-obstructive Azoospermia: A Multi-center Study\",\"authors\":\"Erman Ceyhan , Mehmet Vehbi Kayra , Eylem Gul Ates , Yalcın Kizilkan , Mesut Altan , Omer Yildirim , Mehmet Hamza Gultekin , Nebil Akdogan , Eray Hasirci , Tufan Cicek , Iyimser Ure , Cem Sah , Aykut Baser , Umit Gul , Hamdi Ozkara , Kadir Emre Akkus , Tahsin Turunc , Andrology Working Group of the Society of Urological Surgery in Turkey\",\"doi\":\"10.1016/j.urology.2024.10.038\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>OBJECTIVE</h3><div>To develop an efficient and easy-to-use nomogram that can predict testicular sperm extraction (TESE) success in men with non-obstructive azoospermia (NOA) by using pre-operative parameters.</div></div><div><h3>MATERIALS AND METHODS</h3><div>Data of 3093 men who underwent TESE for NOA were included in this study. Demographic data, testis volumes, presence of varicocele, length of infertility, history of previous surgeries, history of genitourinary infections, smoking status, chromosome abnormalities, presence of Y-chromosome microdeletion, family history of infertility, testis biopsy, surgical data, sperm retrieval rate, final pathology obtained at TESE, follicle-stimulating hormone, luteinizing hormone, and testosterone levels were recorded. The primary outcome was to develop an efficient nomogram that can predict the TESE success in men with NOA. The secondary outcomes were identifying the significant pre-operative parameters that are associated with success in TESE.</div></div><div><h3>RESULTS</h3><div>Sperm retrieval rate was 50.2%(1553/3093). Testis volume, history of varicocelectomy, chromosome abnormalities, and presence of Y-chromosome microdeletion were shown to affect sperm retrieval rate significantly (<em>P</em> <.05). Sperm retrieval success was higher in men with older age, higher testis volume (>10 mL), lower follicle-stimulating hormone level (≤12.92 mIU/mL), lower luteinizing hormone level, and higher testosterone level (<em>P</em> <.05). Only testis volume and patient’s age were associated with successful sperm retrieval in multivariate logistic regression analysis.</div></div><div><h3>CONCLUSION</h3><div>In men with NOA, high testis volume, old age, low follicle-stimulating hormone level, low luteinizing hormone level, and high testosterone level are advantageous for successful sperm retrieval in TESE. 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A Nomogram Predicting Testicular Sperm Extraction Success in Men With Non-obstructive Azoospermia: A Multi-center Study
OBJECTIVE
To develop an efficient and easy-to-use nomogram that can predict testicular sperm extraction (TESE) success in men with non-obstructive azoospermia (NOA) by using pre-operative parameters.
MATERIALS AND METHODS
Data of 3093 men who underwent TESE for NOA were included in this study. Demographic data, testis volumes, presence of varicocele, length of infertility, history of previous surgeries, history of genitourinary infections, smoking status, chromosome abnormalities, presence of Y-chromosome microdeletion, family history of infertility, testis biopsy, surgical data, sperm retrieval rate, final pathology obtained at TESE, follicle-stimulating hormone, luteinizing hormone, and testosterone levels were recorded. The primary outcome was to develop an efficient nomogram that can predict the TESE success in men with NOA. The secondary outcomes were identifying the significant pre-operative parameters that are associated with success in TESE.
RESULTS
Sperm retrieval rate was 50.2%(1553/3093). Testis volume, history of varicocelectomy, chromosome abnormalities, and presence of Y-chromosome microdeletion were shown to affect sperm retrieval rate significantly (P <.05). Sperm retrieval success was higher in men with older age, higher testis volume (>10 mL), lower follicle-stimulating hormone level (≤12.92 mIU/mL), lower luteinizing hormone level, and higher testosterone level (P <.05). Only testis volume and patient’s age were associated with successful sperm retrieval in multivariate logistic regression analysis.
CONCLUSION
In men with NOA, high testis volume, old age, low follicle-stimulating hormone level, low luteinizing hormone level, and high testosterone level are advantageous for successful sperm retrieval in TESE. Herein, we present a nomogram that can predict the outcome of TESE in men with NOA with adequate success.
期刊介绍:
Urology is a monthly, peer–reviewed journal primarily for urologists, residents, interns, nephrologists, and other specialists interested in urology
The mission of Urology®, the "Gold Journal," is to provide practical, timely, and relevant clinical and basic science information to physicians and researchers practicing the art of urology worldwide. Urology® publishes original articles relating to adult and pediatric clinical urology as well as to clinical and basic science research. Topics in Urology® include pediatrics, surgical oncology, radiology, pathology, erectile dysfunction, infertility, incontinence, transplantation, endourology, andrology, female urology, reconstructive surgery, and medical oncology, as well as relevant basic science issues. Special features include rapid communication of important timely issues, surgeon''s workshops, interesting case reports, surgical techniques, clinical and basic science review articles, guest editorials, letters to the editor, book reviews, and historical articles in urology.