血红蛋白、白蛋白、淋巴细胞和血小板(HALP)评分与睾丸肿瘤侵袭性和预后的关系。

IF 0.8 Q4 UROLOGY & NEPHROLOGY Urologia Journal Pub Date : 2024-10-26 DOI:10.1177/03915603241292199
Ozgur Ekici, Ugur Akgun, Erkan Buyukdemirci, Sinan Avci, Volkan Caglayan, Abdullah Erdogan, Efe Onen, Ridvan Ozcan, Sedat Oner
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引用次数: 0

摘要

背景:血红蛋白、白蛋白、淋巴细胞和血小板(HALP)评分综合了反映全身炎症、营养状况和免疫反应的现成血液标记物,所有这些标记物都可能影响癌症的进展。本研究调查了睾丸肿瘤患者的 HALP 评分与临床病理特征之间的关系:方法:回顾 2020 年 1 月至 2024 年 1 月期间因睾丸肿瘤接受根治性睾丸切除术的患者数据。记录术前血清肿瘤标志物、血象参数和白蛋白水平。根据术后放射成像和血清肿瘤标志物记录肿瘤分期。分析了术后结果与 HALP 评分之间的关联:研究共纳入了 74 名男性患者。患者的平均年龄为(30.27 ± 6.42)岁。有转移和腹膜后淋巴结侵犯(RPLNI)的患者组的平均HALP评分明显低于无转移和RPLNI的患者。据统计,HALP 评分随着肿瘤 T 期、N 期和 M 期的增加而明显降低。此外,接受化疗、病情恶化和死亡的患者的 HALP 评分均值在统计学上明显低于未接受化疗的患者:结论:HALP评分越低,睾丸肿瘤患者的病情越晚,预后越差。HALP评分由常规测量的血液标记物组成,可作为一种方便且经济有效的预后工具,用于识别高危患者并指导个性化治疗策略。
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Association of hemoglobin, albumin, lymphocyte and platelet (HALP) score with testicular tumor aggressiveness and prognosis.

Background: The hemoglobin, albumin, lymphocyte and platelet (HALP) score integrates readily available blood markers that reflect systemic inflammation, nutritional status, and immune response, all of which can influence cancer progression. This study investigated the association between the HALP score and clinicopathological characteristics in patients with testicular tumor.

Methods: Data of patients who underwent radical orchiectomy for testicular tumors between January 2020 and January 2024 were reviewed. Preoperative serum tumor markers, hemogram parameters and albumin levels were recorded. Tumor stages were recorded from postoperative radiological imaging and serum tumor markers. The association between postoperative results and HALP score was analyzed.

Results: A total of 74 male patients were included in the study. The mean age of the patients was 30.27 ± 6.42 years. The mean HALP score in the patient group with metastasis and retroperitoneal lypmh node invasion (RPLNI) was statistically significantly lower than the patients without metastasis and RPLNI. HALP score decreased statistically significantly with increasing tumor T stage, N stage and M stage. In addition, the mean HALP score values of patients who received chemotherapy, developed progression and mortality were statistically significantly lower than those of patients who did not.

Conclusions: Lower HALP scores are significantly associated with advanced disease and poorer prognosis in patients with testicular tumor. The HALP score, composed of routinely measured blood markers, may serve as a convenient and cost-effective prognostic tool to identify patients at higher risk and guide personalized management strategies.

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来源期刊
Urologia Journal
Urologia Journal UROLOGY & NEPHROLOGY-
CiteScore
0.60
自引率
12.50%
发文量
66
期刊最新文献
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