针对急性支气管炎住院婴儿的不同治疗策略的疗效。

IF 3.2 Q1 PEDIATRICS Clinical and Experimental Pediatrics Pub Date : 2024-11-01 Epub Date: 2024-10-28 DOI:10.3345/cep.2023.01676
Hyeri Jeong, Dawon Park, Eun Kyo Ha, Ju Hee Kim, Jeewon Shin, Hey-Sung Baek, Hyunsoo Hwang, Youn Ho Shin, Hye Mi Jee, Man Yong Han
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引用次数: 0

摘要

背景: :急性支气管炎是婴儿期住院治疗的常见原因,其发病率和死亡率都很高:本研究从住院时间和临床严重程度评分方面比较了不同治疗方法对婴儿支气管炎的疗效:方法:在 PubMed 数据库中搜索相关研究。资格标准包括双盲随机对照试验设计、评估治疗对两岁以下婴儿支气管炎的影响、从开始到2020年7月31日以英语发表。主要疗效结果为住院时间,次要结果为临床严重程度评分。计算了标准化治疗效果和效果大小的标准误差:我们确定了 45 项随机对照试验,24 项成对比较。这 45 项试验包括 5,061 名参与者,研究了 13 种干预方法(12 种活性方法,1 种安慰剂)。与普通生理盐水相比,肾上腺素吸入疗法(标准平均差 [SMD],-0.41;95% 置信区间 [CI],-0.8 至 -0.03)和高渗盐水(SMD,-0.29;95% 置信区间 [CI],-0.55 至 -0.03)缩短了住院时间。结论:使用肾上腺素和高渗盐水进行吸入治疗可缩短住院时间,减轻两岁以下婴儿支气管炎的临床严重程度。
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Efficacies of different treatment strategies for infants hospitalized with acute bronchiolitis.

Background: Acute bronchiolitis is a common cause of hospitalization during infancy that carries significant morbidity and mortality rates.

Purpose: This study compared the efficacy of different treatment modalities for infants with bronchiolitis in terms of hospital stay and clinical severity scores.

Methods: The PubMed database was searched for relevant studies. Eligibility criteria included double-blind randomized controlled trial design, assessment of the effect of treatment on bronchiolitis in infants under 2 years of age, and publication in English from inception through July 31, 2020. The primary efficacy outcome was the length of hospital stay, while the secondary outcome was the clinical severity score. The standardized treatment effect and standard error of the effect size were calculated.

Results: We identified 45 randomized controlled trials of 24 pairwise comparisons. These 45 trials included 5,061 participants and investigated 13 types of interventions (12 active, 1 placebo). Inhalation therapy with epinephrine (standard mean difference [SMD], -0.41; 95% confidence interval [CI], -0.8 to -0.03) and hypertonic saline (SMD, -0.29; 95% CI, -0.55 to -0.03) reduced the length of hospital stay compared with normal saline. Hypertonic saline was the most effective at improving the clinical severity score (SMD, -0.52; 95% CI, -0.95 to -0.10).

Conclusion: Inhalation therapy with epinephrine and hypertonic saline reduced the length of hospital stay and the clinical severity of bronchiolitis among infants under 2 years of age.

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CiteScore
8.00
自引率
2.40%
发文量
88
审稿时长
60 weeks
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