老年患者的先天性风险。

Q3 Medicine Tunisie Medicale Pub Date : 2024-10-05 DOI:10.62438/tunismed.v102i10.4970
Zohra Chadli, Kmar Kasraoui, Ibtissem Hannachi, Amel Chaabane, Rim Klii, Haifa Ben Romdhane, Naceur A Boughattas, Nadia Ben Fredj, Karim Aouam
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引用次数: 0

摘要

导言--目的:老年人的先天性风险因其频发性和严重性而成为一个真正的公共卫生问题。我们的研究旨在分析发生在老年人身上的药物不良反应的流行病学、临床和年代学方面的情况,并确定引起不良反应的药物:我们对莫纳斯提尔临床药理学部门在 17 年内(2004-2020 年)收到的所有老年患者药物不良反应观察结果进行了回顾性研究。根据ENDA建议进行了药物皮试,并采用法国贝高(Bégaud)等人的方法分析了可归因性:结果:在老年受试者发生的 545 起事件中,有 209 名患者保留了药物责任。其中男性 106 人,女性 103 人(性别比=1.03)。患者的平均年龄为(72.3±6)岁。药物过敏反应占所有不良反应的 75%。这些反应大多为 IV 型(延迟型)。引起不良反应的药物包括:抗感染药物(47%)、肌肉骨骼系统药物(20%)、心血管系统药物(17%)和中枢神经系统药物(5%):通过这项研究,我们注意到延迟性药物超敏反应占主导地位,而且抗感染药物和别嘌呤醇在老年人群不良反应中的参与度更高。
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Iatrogenic risk in elderly patients.

Introduction-Aim: The iatrogenic risk in the elderly is a real public health problem due to its frequency and seriousness. Our study aimed to analyze the epidemiological, clinical and chronological aspects of adverse drug reactions occurring in elderly subjects and to identify the incriminated drugs.

Methods: We carried out a retrospective study of all the observations of adverse drug reactions in elderly subjects, notified to the Clinical Pharmacology department of Monastir over a period of 17 years (2004 - 2020). Drug skin tests were performed according to ENDA recommendations and imputability was analyzed using the French method of Bégaud et al. The drugs have been grouped according to the ATC classification.

Results: Among 545 events occurring in elderly subjects, drug responsibility was retained in 209 patients. They were 106 men and 103 women (gender-ratio=1.03). The average age of the patients was 72.3±6 years. Drug hypersensitivity reactions accounted for 75% of all adverse effects. The majority of these reactions were type IV (delayed). The incriminated drugs were: anti-infectives (47%), drugs for the musculoskeletal system (20%), drugs for the cardiovascular system (17%) and drugs for the central nervous system (5%).

Conclusion: Through this study, we noted a predominance of delayed drug hypersensitivity reactions as well as an increased involvement of anti-infectives and allopurinol in the occurrence of adverse effects in the elderly population.

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来源期刊
Tunisie Medicale
Tunisie Medicale Medicine-Medicine (all)
CiteScore
1.00
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0.00%
发文量
72
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