影响癫痫儿童丙戊酸谷值水平的因素。

Q3 Medicine Tunisie Medicale Pub Date : 2024-10-05 DOI:10.62438/tunismed.v102i10.4881
Khouloud Ferchichi, Rim Charfi, Syrine Ben Hammamia, Mouna Ben Sassi, Emna Gaies, Mouna Daldoul, Riadh Daghfous, Sameh Trabelsi
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引用次数: 0

摘要

研究目的本研究旨在评估影响丙戊酸(V.Acid)血浆谷值(C0)的主要因素,并确定这些因素对接受治疗药物监测(TDM)的癫痫患儿 V.Acid C0 的影响程度:我们在临床药理学系开展了一项观察性研究,研究对象包括年龄在 2 到 18 岁之间的全身性癫痫发作患者。只有至少进行过两次 V.Acid C0 测定的儿童才被纳入研究范围。首先,我们对执业医师进行的每日剂量优化进行了评估。然后,我们将人群分为两组:A 组最终 V.Acid C0 在治疗范围内(TR),B 组最终 V.Acid C0 在治疗范围外,以找出影响 V.Acid C0 旅程的因素:我们共纳入了 805 名患者(2537 例 V.Acid C0)。中位年龄为 6.24 岁,性别比(男/女)为 1.45。V.A酸正常化日剂量中位数为27.27毫克/千克/天,V.A酸C0中位数为57微克/毫升。59.4%的患儿首次V.A酸C0值是在TR中得出的,72.3%的患儿的V.A酸每日剂量是由医生优化的。对比 A 组和 B 组,我们发现年龄和 V.Acid C0 测定次数分别增加了 3.79% 和 7.39% 达到 TR 的几率:结论:年龄越大、V.酸 C0 检测次数越多的儿童越有可能达到 TR 值。对于V.A酸TDM的受益儿童,必须进行密切随访,以达到并维持治疗性V.A酸C0。
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Factors influencing valproic acid trough levels in epileptic children.

Objective: In this study, we aimed to assess main factors influencing the Valproic Acid (V.Acid) plasma trough levels (C0) and to determine their degree of influence on V.Acid C0 in children with epilepsy who had Therapeutic Drug Monitoring (TDM).

Methods: We conducted an observational study in the Department of Clinical Pharmacology including patients with generalized seizures' epilepsy aged between two and 18 years. Only the children that had benefited from at least two V.Acid C0 determinations were included. First, we assessed daily dose optimization, performed by the practitioners. Then we divided our population into two groups: group A with a final V.Acid C0 in the therapeutic range (TR) and group B with a final V. Acid C0 outside the TR to find out factors influencing V.Acid C0 journey.

Results: We included 805 patients (2537 V.Acid C0). The median age was 6.24 years and the sex ratio (M/F) was 1.45. The median V.Acid normalized daily dose was 27.27mg/kg/day and the median V.Acid C0 was 57µg/mL. The children's first V.Acid C0 was in the TR in 59.4% and V.Acid daily dose optimization was performed by the practitioners in 72.3%. Comparing GroupA and B, we found that age and the number of V.Acid C0 determinations increases the chance to reach the TR by respectively 3.79% and 7.39%.

Conclusion: Older children who benefit from higher number of performed V.Acid C0 were more likely to reach the TR. In children who beneficiate from a TDM of V.Acid, close follow-up is mandatory to reach and maintain therapeutic V.Acid C0.

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来源期刊
Tunisie Medicale
Tunisie Medicale Medicine-Medicine (all)
CiteScore
1.00
自引率
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发文量
72
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