社交恐惧症的病因和药物治疗中与羟色胺相关的机制,综述》(Serotonin related Mechanisms in the Etiology and Pharmacotherapy of Social Phobia, A Review.

IF 0.5 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Galen Medical Journal Pub Date : 2023-12-18 eCollection Date: 2023-01-01 DOI:10.31661/gmj.v12i.3072
Malihe Arjmandi Ghandashtani, Sahar Poudineh, Alireza Sarlak, Maryam Poudineh
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引用次数: 0

摘要

社交焦虑症(SAD),又称社交恐惧症,被认为是一种普遍的精神疾病,其特征是对社交场合的持续恐惧。社交恐惧症通常与其他精神障碍同时出现,包括抑郁症和药物滥用症。尽管社交恐惧症被认为是最常见的精神障碍类型之一,但由于临床医生只关注继发性并发症,因此对于反复发作的精神疾病合并症,可能会影响到正确的治疗。此外,尽管社交恐惧症被描述为一种多基因的复杂病症,但很少有基因和表观遗传因素被确定为致病因素。在过去的几十年里,有几项研究表明,血清素能和多巴胺能相关基因的多态性是社交恐惧症的病因。另一方面,血清素作为中枢神经系统(CNS)中必需的神经递质,参与了包括社交恐惧症在内的多种疾病过程。然而,人们对血清素依赖性疾病发展的确切机制以及所建议的药物疗法的疗效并不完全了解。本研究旨在回顾 SAD 的血清素依赖性发病机制,并讨论目前建议的基于血清素代谢的策略。
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Serotonin-related Mechanisms in the Etiology and Pharmacotherapy of Social Phobia, A Review.

Social anxiety disorder (SAD), known as social phobia, is considered a prevalent psychiatric disorder characterized by a constant fear of social positions. Frequently, social phobia occurs with other mental disorders including depression and substance abuse conditions. Although SAD is considered one of the most common types of mental disorders, proper management may be compromised in recurrent psychiatric comorbidity due to clinicians' focus on secondary complications. Moreover, despite the description of social phobia as a polygenic and complex condition, few altered genetic and epigenetic factors are identified as causative agents. Over the past decades, several studies have suggested polymorphisms in serotonergic and dopaminergic-related genes as the etiology of social phobia. Serotonin, on the other hand, as a necessary neurotransmitter in the central nervous system (CNS), is involved in a variety of disease processes including social phobia. Nevertheless, the exact mechanism of serotonin-dependent development of the disease and the efficacy of suggested pharmacotherapies are not fully understood. The current study aimed to review the serotonin-dependent mechanisms by which SAD develops and discuss the current suggested strategies that are based on serotonin metabolism.

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Galen Medical Journal
Galen Medical Journal MEDICINE, RESEARCH & EXPERIMENTAL-
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期刊介绍: GMJ is open access, peer-reviewed journal in English and supported by Noncommunicable Diseases (NCD) Research Center of Fasa University of Medical Sciences that publishing by Salvia Medical Sciences Ltd. GMJ will consider all types of the following scientific papers for publication: - Editorial’s choice - Original Researches - Review articles - Case reports - Case series - Letter (to editors, to authors, etc) - Short communications - Medical Idea
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