重启肺部发育:治疗支气管肺发育不良的新方法。

IF 5.8 2区 医学 Q1 Medicine Respiratory Research Pub Date : 2024-10-24 DOI:10.1186/s12931-024-02996-8
Xuewei Cui, Jianhua Fu
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引用次数: 0

摘要

支气管肺发育不良(BPD)是早产儿最主要的慢性肺部疾病,与各种不良的长期预后有关。多种产前和产后风险因素会阻碍肺部发育,从而导致 BPD。目前对 BPD 的治疗主要依赖于药物疗法和通气策略的改变。然而,这些干预措施只能缓解 BPD 的症状,却无法解决潜在的肺泡、血管、结构和功能缺陷。鉴于BPD婴儿肺部发育迟缓以及现有模式的局限性,新的治疗方法势在必行。干细胞/祖细胞的诱导分化以及与肺部发育过程相关的生长因子的时空表达模式对 BPD 的肺部发育再激活至关重要,其重点在于刺激肺血管生成和肺泡化。本综述总结了肺发育过程,并全面概述了旨在重启 BPD 肺发育的疗法的进展。此外,我们还评估了这些疗法通过干细胞/祖细胞和生长因子维持肺稳态并有效恢复肺结构和功能的潜力。
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Reinitiating lung development: a novel approach in the management of bronchopulmonary dysplasia.

Bronchopulmonary dysplasia (BPD) is the predominant chronic lung disease in preterm infants, linked with various adverse long-term outcomes. Multiple prenatal and postnatal risk factors can impede lung development, leading to BPD. Current management of BPD relies heavily on pharmacotherapies and alterations in ventilatory strategies. However, these interventions only mitigate BPD symptoms without addressing underlying alveolar, vascular, structural, and functional deficiencies. Given the retarded lung development in infants with BPD and the limitations of existing modalities, new therapeutic approaches are imperative. The induced differentiation of stem/progenitor cells and the spatiotemporal expression patterns of growth factors associated with lung developmental processes are critical for lung development reactivation in BPD, which focuses on stimulating pulmonary vasculogenesis and alveolarization. This review summarizes the process of lung development and offers a comprehensive overview of advancements in therapies designed to reinitiate lung development in BPD. Furthermore, we assessed the potential of these therapies for maintaining lung homeostasis and effectively restoring pulmonary structure and function through stem/progenitor cells and growth factors, which have been widely researched.

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来源期刊
Respiratory Research
Respiratory Research RESPIRATORY SYSTEM-
CiteScore
9.70
自引率
1.70%
发文量
314
审稿时长
4-8 weeks
期刊介绍: Respiratory Research publishes high-quality clinical and basic research, review and commentary articles on all aspects of respiratory medicine and related diseases. As the leading fully open access journal in the field, Respiratory Research provides an essential resource for pulmonologists, allergists, immunologists and other physicians, researchers, healthcare workers and medical students with worldwide dissemination of articles resulting in high visibility and generating international discussion. Topics of specific interest include asthma, chronic obstructive pulmonary disease, cystic fibrosis, genetics, infectious diseases, interstitial lung diseases, lung development, lung tumors, occupational and environmental factors, pulmonary circulation, pulmonary pharmacology and therapeutics, respiratory immunology, respiratory physiology, and sleep-related respiratory problems.
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