多种转录因子的共同表达与分泌生长激素的垂体腺瘤的临床特征和内分泌预后有关。

IF 3 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM Endocrine Pub Date : 2024-10-25 DOI:10.1007/s12020-024-04082-x
Yu Zhang, Hanlu Tang, Shiwei Li, Zhixu Bie, Xin Ma, Hongyu Wu, Gemingtian Liu, Xingchao Wang, Pinan Liu, Zhijun Yang
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引用次数: 0

摘要

背景:分泌生长激素的垂体腺瘤类型多种多样,我们发现PIT-1单细胞谱生长激素腺瘤与生长激素表型多激素腺瘤在临床特征和预后方面存在显著差异:本研究对193例生长激素分泌型垂体腺瘤(GHPA)患者进行了研究,将其分为两组:PIT-1单转录因子阳性生长激素腺瘤(STF-GHPA)和多转录因子阳性生长激素分泌腺瘤(MTF-GHPA)。目的是比较这两组肿瘤的临床特征。在 MTF-GHPA 组中,我们根据转录因子对其进行了进一步细分,以评估临床表现的潜在差异。我们采用逻辑回归分析建立了一个风险因素模型,用于研究影响激素缓解的因素:结果:被诊断为MTF-GHPA和STF-GHPA的患者在年龄、性别、血清GH和IGF-1水平方面均无统计学差异。然而,与 STF-GHPA 患者相比,MTF-GHPA 患者垂体功能减退的比例更高。此外,MTF-GHPA 的特点是肿瘤体积较小,侵袭性较低,Knosp 分级也较低。然而,MTF-GHPA 患者的激素缓解率较低(30.8%),术后并发症较多(31.0%),这意味着 STF-GHPA (激素缓解率:71.6%;术后并发症:13.4%)的内分泌疗效优于 MTF-GHPA 患者。在MTF-GHPA中的PIT-1 + SF-1+亚型和PIT-1 + TPIT+亚型之间,肿瘤大小、内分泌疗效和术后并发症也存在显著差异。影响GHPA激素缓解的风险因素包括术前GH水平、原发性/复发性、切除范围和转录因子表达:结论:多种转录因子的共同表达是与GHPA患者临床表现和内分泌结果相关的重要因素。
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Co-expression of multiple transcription factors is associated with clinical features and endocrine prognosis in growth hormone-secreting pituitary adenomas.

Background: The types of growth hormone-secreting pituitary adenomas are diverse, we have found that there are significant differences in clinical features and prognosis between PIT-1 single-cell spectrum growth hormone adenomas and growth hormone phenotypic polyhormonal adenomas.

Methods: This study examined a cohort of 193 patients with growth hormone-secreting pituitary adenoma (GHPA), stratifying them into two groups: PIT-1 single transcription factor positive growth hormone adenoma (STF-GHPA) and Multiple transcription factor-positive growth hormone-secreting adenomas (MTF-GHPA). The objective was to compare these two groups' clinical characteristics. Within the MTF-GHPA group, we further subtyped them based on transcription factors to evaluate potential variations in clinical manifestations. Logistic regression analyses were employed to develop a risk factor model for investigating factors influencing hormone remission.

Results: There were no statistically significant differences in terms of age, gender, serum GH, and IGF-1 levels between patients diagnosed with MTF-GHPA and STF-GHPA. However, patients with MTF-GHPA exhibited a higher proportion of hypopituitarism compared to those with STF-GHPA. Furthermore, MTF-GHPA were characterized by smaller tumor size and less invasiveness, as indicated by lower Knosp classes. However, patients with MTF-GHPA have a lower rate of hormonal remission (30.8%) and more postoperative complications (31.0%), which means that STF-GHPA (hormonal remission:71.6%; postoperative complications:13.4%) has a better endocrine outcome than MTF-GHPA patients. Between the PIT-1 + SF-1+ and PIT-1 + TPIT+ subtypes within MTF-GHPA, significant differences were also observed in tumor size, endocrine outcomes, and postoperative complications. Risk factors influencing hormonal remission for GHPA included preoperative GH level, primary/recurrent, extent of resection, and transcription factor expression.

Conclusion: Co-expression of multiple transcription factors is an important factor associated with clinical behavior and endocrine outcomes in patients with GHPA.

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来源期刊
Endocrine
Endocrine ENDOCRINOLOGY & METABOLISM-
CiteScore
6.50
自引率
5.40%
发文量
295
审稿时长
1.5 months
期刊介绍: Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.
期刊最新文献
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