伊拉克苏莱曼尼亚医院耐抗生素铜绿假单胞菌的分布和分子特征。

Seenaa Muhammed Ali, Taib Ahmed Hama Soor, Gashin Awat Ahmed, Glena Aziz Mhdin, Gulabakh Ali Othman, Sarkhel Mhamad Faiq
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摘要

铜绿假单胞菌是医院环境中的重要病原体,因其在医院获得性感染中的作用及其对多种抗生素产生耐药性的能力而臭名昭著。本研究调查了苏莱曼尼亚市七家医院中铜绿假单胞菌的流行率、分布和抗生素耐药性基因图谱。研究人员从医院的各种表面(包括拖把、水槽、医疗设备、床、办公桌和地板)共收集了 300 份样本。通过细菌学、生化和分子方法,66 个分离物被确认为假单胞菌,其中 26 个被鉴定为铜绿假单胞菌。抗生素药敏试验显示,对链霉素的耐药率为 23.3%,对妥布霉素的耐药率为 13.6%,对莫西沙星的耐药率为 22.7%,对左氧氟沙星的耐药率为 21.2%,对诺氟沙星的耐药率为 22.7%。此外,抗生素耐药基因检测显示,分离物中存在 bla CTX-M、bla SHV、qnrB 和 bla ACC-1 基因。研究结果表明,医院表面的假单胞菌污染率高达 22%,因此迫切需要加强感染控制措施和有针对性的抗菌药物管理,以控制和减少耐多药铜绿假单胞菌的传播。
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Distribution and Molecular Characterization of Antibiotic-Resistant Pseudomonas aeruginosa in Hospital Settings of Sulaymaniyah, Iraq.

Pseudomonas aeruginosa is a significant pathogen in hospital settings, notorious for its role in hospital-acquired infections and its ability to develop resistance to multiple antibiotics. This study investigates the prevalence, distribution, and antibiotic resistance gene profiles of P. aeruginosa in seven hospitals in Sulaymaniyah City. A total of 300 samples were collected from various hospital surfaces including mops, sinks, medical equipment, beds, desks, and floors. Using bacteriological, biochemical, and molecular methods, 66 isolates were confirmed as Pseudomonas species, with 26 identified as P. aeruginosa. Antibiotic susceptibility testing revealed resistance rates of 23.3% to streptomycin, 13.6% to tobramycin, 22.7% to moxifloxacin, 21.2% to levofloxacin, and 22.7% to norfloxacin. Furthermore, the antibiotic resistance gene detection showed the presence of the bla CTX-M, bla SHV, qnrB, and bla ACC-1 genes among the isolates. The study highlights a 22% contamination rate of hospital surfaces with Pseudomonas species, emphasizing the urgent need for enhanced infection control measures and targeted antimicrobial stewardship to manage and reduce the spread of multidrug-resistant P. aeruginosa.

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