皮肤稳态中的 ACKR3--CXCR4/CXCL12 轴中被忽视的角色

Gabriela Cuesta-Margolles, Géraldine Schlecht-Louf, Françoise Bachelerie
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引用次数: 0

摘要

CXCL12 及其受体 CXCR4 是确保皮肤稳态的复杂过程网络中的关键调节因子。在这篇综述中,我们将讨论它们在稳态皮肤中的空间分布和功能;深入探讨它们在急性伤口愈合中的作用,重点是纤维化和再生反应;并探讨它们在皮肤对寄生虫和病原体的反应中的相关性。鉴于对 CXCL12 的非典型受体 ACKR3 缺乏了解,我们推测它是否以及如何参与上述过程。ACKR3 是喜欢错过聚会的(典型)朋友,还是我们需要仔细观察一下?
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ACKR3 in Skin Homeostasis, an Overlooked Player in the CXCR4/CXCL12 Axis.

CXCL12 and its receptor CXCR4 emerge as critical regulators within the intricate network of processes ensuring skin homeostasis. In this review, we discuss their spatial distribution and function in steady-state skin; delve into their role in acute wound healing, with emphasis on fibrotic and regenerative responses; and explore their relevance in skin responses to commensals and pathogens. Given the lack of knowledge surrounding ACKR3, the atypical receptor of CXCL12, we speculate whether and how it might be involved in the processes mentioned earlier. Is ACKR3 the (a)typical friend who enjoys missing the party, or do we need to take a closer look?

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