治疗骨质疏松症的同化制剂的最新情况。

IF 4.6 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Endocrinology and Metabolism Clinics of North America Pub Date : 2024-12-01 Epub Date: 2024-09-26 DOI:10.1016/j.ecl.2024.08.003
Luigi di Filippo MD , Clifford J. Rosen MD
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引用次数: 0

摘要

近几十年来,具有同化骨质特性的新型治疗药物不断问世,目前已被用于治疗骨质疏松症,尤其是脆性骨折高危患者。这些药物包括 PTH 相关类似物、特立帕肽(teriparatide)和阿帕帕肽(abaloparatide),以及抗硬骨生成素药物罗莫索单抗(romosozumab),后者目前仅获准用于女性患者。这两种药物在预防脆性骨折方面的疗效已得到广泛证实,其潜在的严重副作用也逐步降低,包括使用特立帕肽的患者发生恶性肿瘤的风险和使用罗莫索单抗的患者发生心血管事件的风险。关于它们对糖皮质激素诱发的骨质疏松症和骨折愈合的疗效,还需要进一步的数据。
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来源期刊
CiteScore
8.00
自引率
0.00%
发文量
80
审稿时长
6 months
期刊介绍: Endocrinology and Metabolism Clinics of North America updates you on the latest trends in patient management, keeps you abreast of the newest advances, and provides a sound basis for choosing treatment options. Published quarterly—in March, June, September, and December—each issue features expert, state-of-the-art reviews on a single topic, including obesity, diabetes, thyroid disease, bone disorders, reproduction, hypertension, and much more.
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