地诺单抗停药后反弹骨折的预防和管理。

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Endocrinology and Metabolism Clinics of North America Pub Date : 2024-12-01 Epub Date: 2024-09-24 DOI:10.1016/j.ecl.2024.08.002
Sumeet Jain MD
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引用次数: 0

摘要

每 14 名停止使用地诺单抗而又未进行连续抗骨质吸收治疗的患者中,就有 1 人发生地诺单抗反弹相关骨折。发生这种情况的原因是错过或延迟使用地诺单抗剂量后骨质过度吸收。这种骨折是多发性的,会改变患者的生活质量。这种现象发生在所有长期使用地诺单抗治疗的患者群体中。在回顾性研究中,平均延迟 7 个月以上的地诺单抗剂量或停用地诺单抗而不进行连续治疗与死亡率增加有关。研究表明,在终止地诺单抗治疗后使用多种药物治疗方案可大大降低椎体骨折反弹的风险。
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Prevention and Management of Denosumab Discontinuation Rebound Fractures
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来源期刊
CiteScore
8.00
自引率
0.00%
发文量
80
审稿时长
6 months
期刊介绍: Endocrinology and Metabolism Clinics of North America updates you on the latest trends in patient management, keeps you abreast of the newest advances, and provides a sound basis for choosing treatment options. Published quarterly—in March, June, September, and December—each issue features expert, state-of-the-art reviews on a single topic, including obesity, diabetes, thyroid disease, bone disorders, reproduction, hypertension, and much more.
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