[人类诱导多能干细胞在扩张型心肌病疾病模型建立和应用中的研究进展]。

Q3 Medicine 生理学报 Pub Date : 2024-10-25
Man-Ting Xie, Bing-Bing Xie, Qiu-Ling Xiang
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引用次数: 0

摘要

扩张型心肌病(DCM)是一种心肌结构和功能异常的非缺血性心肌病。由于伦理方面的限制,从 DCM 患者身上构建人类原代心肌细胞具有挑战性。此外,动物模型也无法充分复制人类疾病的复杂性。DCM 的发病机制仍不清楚。人类诱导多能干细胞(hiPSCs)的出现为 DCM 的基础研究提供了新的工具。研究人员制备了源于 hiPSCs 的心肌细胞(hiPSC-CMs),并将其应用于药物筛选,从而对 DCM 的病理机制和治疗方法有了新的认识。本综述总结了 DCM 患者特异性 hiPSC-CMs (DCM-hiPSC-CMs)模型的建立、药物筛选和机制研究进展。
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[Research progress of human induced pluripotent stem cells in the establishment and application of dilated cardiomyopathy disease model].

Dilated cardiomyopathy (DCM) is a non-ischemic cardiomyopathy with abnormal myocardial structure and function. It is challenging to construct human primary cardiac myocytes from DCM patients due to ethical constraints. In addition, animal models failed to adequately replicate the complexity of the human disease. The mechanism of DCM remains unclear. The emergence of human induced pluripotent stem cells (hiPSCs) provides a new tool for basic research in DCM. Researchers have produced hiPSCs-derived cardiomyocytes (hiPSC-CMs) and applied them to drug screening, leading to new insight into the pathomechanism and treatment in DCM. This review summarizes the research progress in the establishment, drug screening and mechanism research of DCM patient-specific hiPSC-CMs (DCM-hiPSC-CMs) model.

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来源期刊
生理学报
生理学报 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
4820
期刊介绍: Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.
期刊最新文献
[Exogenous EPO protects HT22 cells from intermittent hypoxia-induced injury by activating JAK2-STAT5 signaling pathway]. [m6A RNA methylation is a potential biological target for neuropathic pain]. [Research progress in the regulation of functional homeostasis of adipose tissue by exosomal miRNA]. [Research progress of human induced pluripotent stem cells in the establishment and application of dilated cardiomyopathy disease model]. [Research progress of the effects of high-intensity interval training on excess post-exercise oxygen consumption in human].
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