脑静脉血栓治疗的最新进展。

IF 4.1 2区 医学 Q1 CLINICAL NEUROLOGY Current Opinion in Neurology Pub Date : 2024-10-22 DOI:10.1097/WCO.0000000000001329
Sara Rosa, Isabel Fragata, Diana Aguiar de Sousa
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引用次数: 0

摘要

综述的目的:本综述旨在系统阐述脑静脉血栓形成(CVT)的诊断和治疗方法,重点介绍近期发表的主要研究:最近的研究结果:鉴于最近的大流行病,CVT 出现了新的危险因素。对比增强磁共振成像(MRI)和感度加权成像(susceptibility-weighted imaging)已被证明可提高检测皮质静脉血栓的灵敏度。仅接受抗凝治疗的患者通常在治疗开始后 8 天就会出现部分静脉再通。小结:CVT 是一种不常见的脑血管疾病,多发于育龄女性。应识别并解决风险因素。诊断依赖于静脉窦和/或静脉血栓形成的确认,通常是通过 CT 静脉造影或核磁共振成像。抗凝是治疗的基础。尽管缺乏高质量的证据,但严重病例通常会考虑血管内治疗。特殊人群需要量身定制的治疗方法。约 80% 的患者可达到 mRS 0-1,但残留症状通常会影响生活质量和重返工作岗位的能力。
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Update on management of cerebral venous thrombosis.

Purpose of review: This review intends to systematize the diagnostic and treatment approach to cerebral venous thrombosis (CVT), highlighting key studies that have been recently published.

Recent findings: In light of the recent pandemic, new risk factors for CVT have emerged. Contrast-enhanced MRI and susceptibility-weighted imaging have been shown to offer increased sensitivity for detecting cortical vein thrombosis.Dabigatran seems to be as effective and well tolerated as warfarin for long-term anticoagulation. Partial venous recanalization often occurs in patients treated with anticoagulation only, as early as 8 days after treatment onset. For patients with CVT and impending brain herniation, two-thirds of those who undergo decompressive craniectomy survive, with one-third being functionally independent 6 months after diagnosis.

Summary: CVT is an unusual type of cerebrovascular disease that mostly affects women of fertile age. Risk factors should be identified and addressed. Diagnosis relies on confirmation of venous sinus and/or vein thrombosis, usually by CT venography or MRI. Anticoagulation is the cornerstone of treatment. Despite the lack of high-quality evidence, endovascular treatment is often considered in severe cases. Special populations require tailored approaches. About 80% achieve mRS 0-1, but residual symptoms often affect quality of life and the ability to return to work.

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来源期刊
Current Opinion in Neurology
Current Opinion in Neurology 医学-临床神经学
CiteScore
8.60
自引率
0.00%
发文量
174
审稿时长
6-12 weeks
期刊介绍: ​​​​​​​​Current Opinion in Neurology is a highly regarded journal offering insightful editorials and on-the-mark invited reviews; covering key subjects such as cerebrovascular disease, developmental disorders, neuroimaging and demyelinating diseases. Published bimonthly, each issue of Current Opinion in Neurology introduces world renowned guest editors and internationally recognized academics within the neurology field, delivering a widespread selection of expert assessments on the latest developments from the most recent literature.
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