Irisin and neuroinflammation: Challenges and opportunities

Irisin is a myokine that is cleaved from 5-domain type III fibronectin (FNDC5), and is known for its metabolic functions as it stimulates browning of white adipose tissue; similarly, effects on the central nervous system have been described, specifically in neurodevelopmental and neuroprotection processes. The purpose of this review is to describe recent information on the effects of irisin on neuroinflammation to contribute to the knowledge about the mechanisms by which irisin and exercise could generate benefits for some neurological diseases. The review conducted found several studies describing the effect of irisin on pathways such as STAT3, p38, cAMP/PKA/CREB, as well as effects on GFAP protein expression or apoptosis processes in both in vitro and in vivo models; likewise, these pathways are associated with better BDNF expression. Despite increasing information on this topic, it is still necessary to clarify the mechanisms by which irisin has effects on neuroinflammation and this could represent an opportunity to generate more treatments for diseases such as Alzheimer's, Parkinson's or Diabetes Mellitus.