是什么阻碍了临床前 GPR119 激动剂发挥治疗 2 型糖尿病的潜力?

IF 4.6 2区 医学 Q1 PHARMACOLOGY & PHARMACY Expert Opinion on Therapeutic Targets Pub Date : 2024-10-29 DOI:10.1080/14728222.2024.2421751
Jing Hu, Yu Cao, Lianxiang Duan, Jinghua Peng
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What is holding back preclinical GPR119 agonists from their potential as the therapeutics of type 2 diabetes?
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来源期刊
CiteScore
8.90
自引率
1.70%
发文量
58
审稿时长
3 months
期刊介绍: The journal evaluates molecules, signalling pathways, receptors and other therapeutic targets and their potential as candidates for drug development. Articles in this journal focus on the molecular level and early preclinical studies. Articles should not include clinical information including specific drugs and clinical trials. The Editors welcome: Reviews covering novel disease targets at the molecular level and information on early preclinical studies and their implications for future drug development. Articles should not include clinical information including specific drugs and clinical trials. Original research papers reporting results of target selection and validation studies and basic mechanism of action studies for investigative and marketed drugs. The audience consists of scientists, managers and decision makers in the pharmaceutical industry, academic researchers working in the field of molecular medicine and others closely involved in R&D.
期刊最新文献
Targeted therapeutic strategies for the kidney. Advantages and disadvantages of targeting senescent endothelial cells in cardiovascular and cerebrovascular diseases based on small extracellular vesicles. Potential molecular targets for the pharmacologic management of non-traumatic osteonecrosis. What is holding back preclinical GPR119 agonists from their potential as the therapeutics of type 2 diabetes? Targeting the TRPV1 pain pathway in osteoarthritis of the knee.
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