添加了scGOS/lcFOS和乳双歧杆菌M-16V合成益生菌混合物的幼儿配方奶粉可改善健康幼儿的肠道微生物群和铁状况。

IF 2.1 3区 医学 Q2 PEDIATRICS Frontiers in Pediatrics Pub Date : 2024-10-14 eCollection Date: 2024-01-01 DOI:10.3389/fped.2024.1193027
Charmaine Chew, Misa Matsuyama, Peter S W Davies, Rebecca J Hill, Mark Morrison, Rocio Martin, Francisco M Codoñer, Jan Knol, Guus Roeselers
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引用次数: 0

摘要

生命早期肠道微生物群的发育取决于高度同步的微生物定植过程,而饮食是其中的关键调节因素。在幼儿期,微生物群向更像成人的状态过渡,这与从以牛奶为基础的饮食向家庭饮食过渡是同步的。出生后第一年的微生物群发育已得到广泛研究,但幼儿期的研究仍然很少。幼儿对膳食铁等微量营养素的需求高于成人。然而,根据常规膳食摄入量,他们的摄入量通常达不到最佳水平。儿童健康与居住地微生物(CHaRM)研究是一项双盲随机对照试验,旨在调查幼儿牛奶与未强化的标准牛奶相比对身体组成的影响,该研究是作为 GUMLi("轻型 "成长牛奶)试验的辅助项目在澳大利亚布里斯班进行的。在这项试验中,将蛋白质含量较低、添加了合生元[乳双歧杆菌 M-16V、短链半乳寡糖和长链果寡糖(比例为 9:1)]和微量营养素的强化牛奶与未强化的标准牛奶进行了比较。在本研究中,我们对完成 CHaRM 研究的 29 名儿童(积极组 18 名,对照组 11 名)进行了调查,以了解干预措施对幼儿肠道微生物群的影响及其与铁状况的关系。幼儿微生物群主要由固醇菌门、类杆菌门和放线菌门的成员组成。通过量化研究发现,对照组的布氏杆菌数量低于活跃组。对血液中铁标记物的分析表明,活跃组的铁状况有所改善。我们观察到双歧杆菌的丰度与血液中铁的状况呈正相关。PICRUSt 是一种基于 16S 核糖体基因测序的预测功能算法,用于将潜在的微生物功能与铁状态测量值联系起来。该分析表明,编码肠杆菌素(肠杆菌科特有的一类嗜苷酸盐)的预测基因的丰度与双歧杆菌属成员的相对丰度成反比。这些研究结果表明,作为健康饮食的一部分,食用添加了合生元的幼儿配方奶粉的健康儿童的肠道对铁的可用性和吸收得到了改善,肠道微生物组中双歧杆菌的数量也有所增加。
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A young child formula supplemented with a synbiotic mixture of scGOS/lcFOS and Bifidobacterium breve M-16V improves the gut microbiota and iron status in healthy toddlers.

Early-life gut microbiota development depends on a highly synchronized microbial colonization process in which diet is a key regulator. Microbiota transition toward a more adult-like state in toddlerhood goes hand in hand with the transition from a milk-based diet to a family diet. Microbiota development during the first year of life has been extensively researched; however, studies during toddlerhood remain sparse. Young children's requirement for micronutrients, such as dietary iron, is higher than adults. However, their intake is usually sub-optimal based on regular dietary consumption. The Child Health and Residence Microbes (CHaRM) study, conducted as an adjunct to the GUMLi (Growing Up Milk "Lite") trial, was a double-blind randomized controlled trial to investigate the effects on body composition of toddler milk compared to unfortified standard cow's milk in healthy children between 1 and 2 years of age in Brisbane (Australia). In this trial, fortified milk with reduced protein content and added synbiotics [Bifidobacterium breve M-16V, short-chain galactooligosaccharides, and long-chain fructooligosaccharides (ratio 9:1)] and micronutrients were compared to standard unfortified cow's milk. In the present study, the effects of the intervention on the gut microbiota and its relationship with iron status in toddlers were investigated in a subset of 29 children (18 in the Active group and 11 in the Control group) who completed the CHaRM study. The toddler microbiota consisted mainly of members of the phyla Firmicutes, Bacteroidota, and Actinobacteriota. The abundance of the B. breve species was quantified and was found to be lower in the Control group than in the Active group. Analysis of blood iron markers showed an improved iron status in the Active group. We observed a positive correlation between Bifidobacterium abundance and blood iron status. PICRUSt, a predictive functionality algorithm based on 16S ribosomal gene sequencing, was used to correlate potential microbial functions with iron status measurements. This analysis showed that the abundance of predicted genes encoding for enterobactin, a class of siderophores specific to Enterobacteriaceae, is inversely correlated with the relative abundance of members of the genus Bifidobacterium. These findings suggest that healthy children who consume a young child formula fortified with synbiotics as part of a healthy diet have improved iron availability and absorption in the gut and an increased abundance of Bifidobacterium in their gut microbiome.

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来源期刊
Frontiers in Pediatrics
Frontiers in Pediatrics Medicine-Pediatrics, Perinatology and Child Health
CiteScore
3.60
自引率
7.70%
发文量
2132
审稿时长
14 weeks
期刊介绍: Frontiers in Pediatrics (Impact Factor 2.33) publishes rigorously peer-reviewed research broadly across the field, from basic to clinical research that meets ongoing challenges in pediatric patient care and child health. Field Chief Editors Arjan Te Pas at Leiden University and Michael L. Moritz at the Children''s Hospital of Pittsburgh are supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Pediatrics also features Research Topics, Frontiers special theme-focused issues managed by Guest Associate Editors, addressing important areas in pediatrics. In this fashion, Frontiers serves as an outlet to publish the broadest aspects of pediatrics in both basic and clinical research, including high-quality reviews, case reports, editorials and commentaries related to all aspects of pediatrics.
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