本月基因C-KIT。

IF 0.9 4区医学 Q4 ONCOLOGY Indian journal of cancer Pub Date : 2024-10-30 DOI:10.4103/ijc.ijc_1350_21

Niraj Kumari, Raghavendra Lingaiah

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引用次数: 0

摘要

摘要：KIT 是酪氨酸激酶受体的编码基因，被确认为干细胞因子的配体。它在疾病中的作用最早是在胃肠道间质瘤中发现的。不过，后来发现该基因与许多其他良性和恶性肿瘤都有关联。C-KIT 已被研究为靶向治疗的首个生物标记物。在此，我们回顾了它的结构、功能以及在各种非肿瘤性和肿瘤性疾病中的作用。

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Gene of the month: C-KIT.

Abstract: KIT is a gene coding for tyrosine kinase receptor, which was identified as the ligand of stem cell factor. Its role in disease was first identified in gastrointestinal stromal tumor. However, later, this gene was found to be implicated in many other benign and malignant tumors. C-KIT has been studied as the first biomarker for targeted therapy. Herein we review its structure, function and role in various non-neoplastic and neoplastic diseases.

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来源期刊

Indian journal of cancer Medicine-Oncology

CiteScore

1.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Indian Journal of Cancer (ISSN 0019-509X), the show window of the progress of ontological sciences in India, was established in 1963. Indian Journal of Cancer is the first and only periodical serving the needs of all the specialties of oncology in India.