体形指数与动脉僵化之间的关系:EVasCu 研究结果和荟萃分析。

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM International Journal of Obesity Pub Date : 2024-10-28 DOI:10.1038/s41366-024-01663-8
Alicia Saz-Lara, Iván Cavero-Redondo, Nerea Moreno-Herráiz, Elena Rescalvo-Fernández, Carlos Berlanga-Macías, María Medrano, Rosa María Fuentes Chacón, Carlos Pascual-Morena
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引用次数: 0

摘要

研究目的本研究旨在利用 EVasCu 研究的数据分析健康受试者的体形指数(ABSI)与动脉僵化之间的关系。此外,还进行了一项荟萃分析,以比较 ABSI 与普通人群的中心、外周和全身动脉僵化之间的关系:EVasCu研究包括390名健康受试者。ABSI根据腰围、体重指数和身高计算,动脉僵化则通过主动脉脉搏波速度(a-PWv)和心踝血管指数(CAVI)评估。对包括 EVasCu 研究数据在内的以往研究进行了荟萃分析,以获得 ABSI 与中心、外周和全身动脉僵化之间相关系数 (r) 的集合估计值及其各自的 95% 置信区间 (95%CI)。此外,还计算了集合 OR 估计值及其 95% CI:结果:在 EVasCu 研究中,相关系数估计值为 0.458(p 结论:在 EVasCu 研究中,相关系数估计值为 0.458:根据 EVasCu 研究和荟萃分析的结果,无论是健康受试者还是有合并症的受试者,ABSI 与动脉僵化之间都存在正相关。ABSI 每增加一个单位 cm/kg/m²/m,中心动脉僵化的风险增加 112%,外周动脉僵化的风险增加 121%,全身动脉僵化的风险增加 199%。然而,在这一知识领域还需要进一步的研究。
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Association between body shape index and arterial stiffness: results of the EVasCu study and a meta-analysis.

Objective: The aim of this study was to analyse the association between body shape index (ABSI) and arterial stiffness in healthy subjects using data from the EVasCu study. In addition, a meta-analysis was performed to compare the association between ABSI and central, peripheral and systemic arterial stiffness in the general population.

Methods: The EVasCu study included 390 healthy subjects. ABSI was calculated from waist circumference, body mass index and height, and arterial stiffness was assessed with aortic pulse wave velocity (a-PWv) and cardio-ankle vascular index (CAVI). A meta-analysis of previous studies, including data from the EVasCu study, was performed to obtain pooled estimates of correlation coefficients (r) and their respective 95% confidence intervals (95% CIs) for the association between ABSI and central, peripheral and systemic arterial stiffness. In addition, pooled OR estimates and their 95% CIs were calculated.

Results: In the EVasCu study, the correlation coefficient estimate was 0.458 (p < 0.01) for the association of a-PWv and ABSI and 0.408 (p < 0.01) for the association of CAVI and ABSI. In the meta-analysis, the pooled correlation coefficient estimate was 0.22 (95% CIs: 0.16, 0.28) for central arterial stiffness and ABSI, 0.21 (95% CIs: 0.14, 0.28) for peripheral arterial stiffness and ABSI, and 0.28 (95% CI: 0.21, 0.3) for systemic arterial stiffness and ABSI. When pooled ORs were calculated, the pooled OR estimate was 2.12 (95% CIs: 1.68, 2.56) for central arterial stiffness and ABSI, 2.21 (95% CIs: 1.81, 2.60) for peripheral arterial stiffness and ABSI, and 2.99 (95% CIs: 2.14, 3.85) for systemic arterial stiffness and ABSI.

Conclusion: Based on both the results obtained in the EVasCu study and the meta-analysis, there is a positive association between ABSI and arterial stiffness, both in healthy subjects and in participants with comorbidities. For each unit of cm/kg/m²/m increase in ABSI, the risk of arterial stiffness increased by 112% for central arterial stiffness, 121% for peripheral arterial stiffness, and 199% for systemic arterial stiffness. However, further research is needed in this field of knowledge.

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来源期刊
International Journal of Obesity
International Journal of Obesity 医学-内分泌学与代谢
CiteScore
10.00
自引率
2.00%
发文量
221
审稿时长
3 months
期刊介绍: The International Journal of Obesity is a multi-disciplinary forum for research describing basic, clinical and applied studies in biochemistry, physiology, genetics and nutrition, molecular, metabolic, psychological and epidemiological aspects of obesity and related disorders. We publish a range of content types including original research articles, technical reports, reviews, correspondence and brief communications that elaborate on significant advances in the field and cover topical issues.
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