双特异性磷酸酶 3 (DUSP3):肾缺血再灌注损伤的潜在靶点

IF 5.3 2区 医学 Q1 IMMUNOLOGY Transplantation Pub Date : 2024-11-01 Epub Date: 2024-04-08 DOI:10.1097/TP.0000000000005009
Badr Khbouz, Lucia Musumeci, Florian Grahammer, François Jouret
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引用次数: 0

摘要

肾脏缺血/再灌注(I/R)损伤是肾移植临床医生面临的常见临床挑战。I/R 是急性肾损伤的主要原因,当肾脏血流中断并随后恢复时就会发生 I/R。I/R 会在短期和长期损害肾功能。肾缺血预处理是指所有旨在预防或减轻缺血性损伤的措施。在此背景下,本综述将重点讨论双特异性磷酸酶 3(DUSP3),它也被称为疫苗 H1 相关磷酸酶,是一种不常见的丝裂原活化蛋白激酶(MAPK)磷酸化调节因子。DUSP3 具有不同的生物学功能:(1)作为肿瘤调节剂;(2)参与调节免疫反应、血栓形成、止血、血管生成和基因组稳定性。这些功能都是通过依赖 MAPK 或不依赖 MAPK 的机制实现的。DUSP3基因缺失可抑制小鼠I/R引起的肾损伤和炎症,这表明DUSP3是预防肾I/R损伤的潜在靶点。在此,我们讨论了 DUSP3 在缺血预处理中的推测作用,以及通过改善肾脏灌注和充分的先天性免疫反应来减轻炎症反应的潜在机制。
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The Dual-specificity Phosphatase 3 (DUSP3): A Potential Target Against Renal Ischemia/Reperfusion Injury.

Renal ischemia/reperfusion (I/R) injury is a common clinical challenge faced by clinicians in kidney transplantation. I/R is the leading cause of acute kidney injury, and it occurs when blood flow to the kidney is interrupted and subsequently restored. I/R impairs renal function in both short and long terms. Renal ischemic preconditioning refers to all maneuvers intended to prevent or attenuate ischemic damage. In this context, the present review focuses on the dual-specificity phosphatase 3 (DUSP3), also known as vaccinia H1-related phosphatase, an uncommon regulator of mitogen-activated protein kinase (MAPK) phosphorylation. DUSP3 has different biological functions: (1) it acts as a tumor modulator and (2) it is involved in the regulation of immune response, thrombosis, hemostasis, angiogenesis, and genomic stability. These functions occur either through MAPK-dependent or MAPK-independent mechanisms. DUSP3 genetic deletion dampens kidney damage and inflammation caused by I/R in mice, suggesting DUSP3 as a potential target for preventing renal I/R injury. Here, we discuss the putative role of DUSP3 in ischemic preconditioning and the potential mechanisms of such an attenuated inflammatory response via improved kidney perfusion and adequate innate immune response.

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来源期刊
Transplantation
Transplantation 医学-免疫学
CiteScore
8.50
自引率
11.30%
发文量
1906
审稿时长
1 months
期刊介绍: The official journal of The Transplantation Society, and the International Liver Transplantation Society, Transplantation is published monthly and is the most cited and influential journal in the field, with more than 25,000 citations per year. Transplantation has been the trusted source for extensive and timely coverage of the most important advances in transplantation for over 50 years. The Editors and Editorial Board are an international group of research and clinical leaders that includes many pioneers of the field, representing a diverse range of areas of expertise. This capable editorial team provides thoughtful and thorough peer review, and delivers rapid, careful and insightful editorial evaluation of all manuscripts submitted to the journal. Transplantation is committed to rapid review and publication. The journal remains competitive with a time to first decision of fewer than 21 days. Transplantation was the first in the field to offer CME credit to its peer reviewers for reviews completed. The journal publishes original research articles in original clinical science and original basic science. Short reports bring attention to research at the forefront of the field. Other areas covered include cell therapy and islet transplantation, immunobiology and genomics, and xenotransplantation. ​
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