ANGPTL4-一种参与葡萄糖代谢、脂质代谢和肿瘤发生的蛋白质。

IF 3.2 4区医学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Journal of Gene Medicine Pub Date : 2024-10-28 DOI:10.1002/jgm.3740

Zhilong Xu, Gening Jiang

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引用次数: 0

摘要

自 2000 年首次发现 ANGPTL4 参与脂质代谢以来，Angptl4 引起了研究人员的关注。随着研究的深入，人们发现 Angptl4 还参与了体内许多生物活动（糖代谢、血管生成、伤口愈合、肿瘤生长等）。在这篇综述中，我们概述了 ANGPTL4 在代谢调节中的基本作用及其对肿瘤生长的影响。这些见解可能会为探索 ANGPTL4 作为未来疾病治疗的潜在治疗靶点提供一条途径。

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ANGPTL4—A protein involved in glucose metabolism, lipid metabolism, and tumor development

Since ANGPTL4 was discovered to be involved in lipid metabolism in 2000 for the first time, Angptl4 has attracted the attention of researchers. With the further research, it was found that angptl4 was also involved in many biological activities (glucose metabolism, angiogenesis, wound healing, tumor growth, etc.) in vivo. In this review, we provide an overview of the fundamental role of ANGPTL4 in metabolic regulation and its impact on tumor growth. These insights may provide a way for exploring ANGPTL4 as a potential therapeutic target for future disease treatments.

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来源期刊

Journal of Gene Medicine 医学-生物工程与应用微生物

CiteScore

6.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The aims and scope of The Journal of Gene Medicine include cutting-edge science of gene transfer and its applications in gene and cell therapy, genome editing with precision nucleases, epigenetic modifications of host genome by small molecules, siRNA, microRNA and other noncoding RNAs as therapeutic gene-modulating agents or targets, biomarkers for precision medicine, and gene-based prognostic/diagnostic studies. Key areas of interest are the design of novel synthetic and viral vectors, novel therapeutic nucleic acids such as mRNA, modified microRNAs and siRNAs, antagomirs, aptamers, antisense and exon-skipping agents, refined genome editing tools using nucleic acid /protein combinations, physically or biologically targeted delivery and gene modulation, ex vivo or in vivo pharmacological studies including animal models, and human clinical trials. Papers presenting research into the mechanisms underlying transfer and action of gene medicines, the application of the new technologies for stem cell modification or nucleic acid based vaccines, the identification of new genetic or epigenetic variations as biomarkers to direct precision medicine, and the preclinical/clinical development of gene/expression signatures indicative of diagnosis or predictive of prognosis are also encouraged.