Yangnan Hu , Hao Wei , Menghui Liao , Shanying Han , Xin Gao , Yusong Wang , Shan Zhou , Dongyu Xu , Xugang Zhuang , Ye Yang , Hong Cheng , Bin Zhang , Qingyue Cui , Jieyu Qi , Lei Tian , Wenyan Li , Xia Gao , Renjie Chai
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引用次数: 0
摘要
人工耳蜗植入术（CI）是治疗感音神经性听力损失的可靠方法，精确的电声刺激参数在改善 CI 患者的听觉效果方面显示出巨大的潜力。在此，我们报告了将 MXene 植入 CI 系统的情况，由于 MXene 具有出色的导电性和生物相容性，它能有效模拟神经电极接口。基于 MXene 的 CI 发出的低频短期双相电脉冲促进了螺旋神经节神经元（SGN）神经元和生长锥的生长，大大提高了 SGN 的钙活性。这项研究为人工耳蜗患者护理中的精准医疗方法奠定了理论基础，并为今后人工耳蜗电极材料的选择提供了参考。
Cochlear implant/MXene-based electroacoustic stimulation modulates the growth and maturation of spiral ganglion neurons
Cochlear implantation (CI) offers a dependable treatment for sensorineural hearing loss, with precision electroacoustic stimulation parameters showing great potential in improving auditory outcomes in CI patients. Here, we report the attachment of MXene into CI systems which effectively mimic the neural electrode interface due to MXene's excellent electrical conductivity and biocompatibility. Low-frequency short-term biphasic electrical pulses emitted by the MXenes-based CI promoted the outgrowth of spiral ganglion neuron (SGN) neurites and growth cones, substantially boosting the calcium activity in SGNs. This study lays a theoretical foundation for the precision medicine approaches in CI patient care, and informs the selection of materials for cochlear implant electrode materials in the future.
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