The synthesis of N-Trifluoromethyl hydroxylamine from (trifluoromethyl)trimethylsilane

We have presented a straightforward approach for the synthesis of N-CF₃ hydroxylamines, utilizing TMSCF₃ for the N-trifluoromethylation of nitrosoarenes with the assistance of CsF. This method demonstrates excellent tolerance towards various functional groups and can be applied to a wide range of substrates, highlighting its versatility and utility in synthetic applications. The nucleophilic N-trifluoromethylation pathway for N-CF₃ hydroxylamines provides a practical protocol for the synthesis of promising molecular architectures in the field of medicinal chemistry.