炎症与老年人的疼痛和疲劳有关

IF 3.7 Q2 IMMUNOLOGY Brain, behavior, & immunity - health Pub Date : 2024-10-18 DOI:10.1016/j.bbih.2024.100874
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引用次数: 0

摘要

导言越来越多的证据表明,炎症可能在老年人慢性疼痛和疲劳的发展过程中起着关键作用。本研究调查了圣路易斯人格与老龄化(SPAN)研究中老年人样本中三种炎症标志物(IL-6、CRP 和 TNFα)与疼痛和疲劳之间的横向和纵向关系。疼痛和疲劳采用 RAND-36 健康状况调查表进行评估。相关性(对多重检验进行假发现率校正)和后续线性回归(包括可能混杂的人口统计学(如家庭年收入)和健康(如体重指数、药物使用)协变量)用于估计横截面和纵向相关性。结果横断面分析显示,IL-6和CRP越高,所报告的疼痛和疲劳程度越大,即使考虑了协变量(βs > .098, ps <.05)。TNFα仅与更大的疲劳相关(β = .100,P = .012)。纵向来看,CRP和IL-6可预测未来的疼痛和疲劳,但只有CRP和未来疲劳之间的关系在纳入协变量后仍然存在(β = .104,p = .022)。疼痛和疲劳都预示着约 2 年后 IL-6 和 CRP 水平的升高,但只有 IL-6 与协变量的关系(βs > .12, ps < .01)存活下来。我们的纵向数据显示了时间上的双向关联,这与非人类动物模型的证据一致,即炎症加剧是导致疲劳的原因之一,同时也表明疼痛和疲劳的体验可能会导致炎症。在未来的工作中,确定与疼痛和疲劳相关的生活方式因素(如体育锻炼)可能如何促进这些关联将非常重要。
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Inflammation is associated with pain and fatigue in older adults

Introduction

Increasing evidence suggests that inflammation may play a pivotal role in the development of chronic pain and fatigue in aging individuals. This study investigated the relationship between three inflammatory markers (IL-6, CRP, and TNFα) and pain and fatigue, both cross-sectionally and longitudinally, in a sample of older adults from the Saint Louis Personality and Aging (SPAN) study.

Methods

SPAN study participants provided blood samples at two in-person sessions approximately 2 years apart for the analysis of the inflammatory biomarkers IL-6, CRP, and TNFα. Pain and fatigue were assessed using the RAND-36 Health Status Inventory. Correlations (with false discovery rate correction for multiple testing) and follow-up linear regressions including potentially confounding demographic (e.g., annual household income) and health (e.g., BMI, medication use) covariates were used to estimate cross sectional and longitudinal associations. Analytic ns ranged from 533 to 815.

Results

Cross-sectional analyses revealed that higher IL-6 and CRP were associated with greater reported pain and fatigue, even after accounting for covariates (βs > .098, ps < .05). TNFα was associated with greater fatigue only (β = .100, p = .012). Longitudinally, CRP and IL-6 predicted future pain and fatigue, although only the relationship between CRP and future fatigue survived the inclusion of covariates (β = .104, p = .022). Both pain and fatigue predicted higher levels of IL-6 and CRP approximately 2 years later, although only the associations with IL-6 survived the inclusion of covariates (βs > .12, ps < .01).

Discussion

Our study adds to a growing body of literature showing that inflammation is associated with greater pain and fatigue in older adults. Our longitudinal data showing temporal bidirectional associations is consistent with evidence from non-human animal models that heightened inflammation causally contributes to fatigue and also suggests that the experience of pain and fatigue may contribute to inflammation. It will be important for future work to identify how lifestyle factors associated with pain and fatigue (e.g., physical activity) may contribute to these associations.
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来源期刊
Brain, behavior, & immunity - health
Brain, behavior, & immunity - health Biological Psychiatry, Behavioral Neuroscience
CiteScore
8.50
自引率
0.00%
发文量
0
审稿时长
97 days
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