Xiang Lv , Jiesi Luo , Yonglin Zhang , Hui Guo , Ming Yang , Menglong Li , Qi Chen , Runyu Jing
{"title":"通过可解释的机器学习揭示 2 型糖尿病的诊断信息","authors":"Xiang Lv , Jiesi Luo , Yonglin Zhang , Hui Guo , Ming Yang , Menglong Li , Qi Chen , Runyu Jing","doi":"10.1016/j.ins.2024.121582","DOIUrl":null,"url":null,"abstract":"<div><div>The interpretability of disease prediction models is often crucial for their trustworthiness and usability among medical practitioners. Existing methods in interpretable artificial intelligence improve model transparency but fall short in identifying precise, disease-specific primal information. In this work, an interpretable deep learning-based algorithm called the data space landmark refiner was developed, which not only enhances both global interpretability and local interpretability but also reveals the intrinsic information of the data distribution. Using the proposed method, a type 2 diabetes mellitus diagnostic model with high interpretability was constructed on the basis of the electronic health records from two hospitals. Moreover, effective diagnostic information was directly derived from the model’s internal parameters, demonstrating strong alignment with current clinical knowledge. Compared with conventional interpretable machine learning approaches, the proposed method offered more precise and specific interpretability, increasing clinical practitioners’ trust in machine learning-supported diagnostic models.</div></div>","PeriodicalId":51063,"journal":{"name":"Information Sciences","volume":"690 ","pages":"Article 121582"},"PeriodicalIF":8.1000,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Unveiling diagnostic information for type 2 diabetes through interpretable machine learning\",\"authors\":\"Xiang Lv , Jiesi Luo , Yonglin Zhang , Hui Guo , Ming Yang , Menglong Li , Qi Chen , Runyu Jing\",\"doi\":\"10.1016/j.ins.2024.121582\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>The interpretability of disease prediction models is often crucial for their trustworthiness and usability among medical practitioners. Existing methods in interpretable artificial intelligence improve model transparency but fall short in identifying precise, disease-specific primal information. In this work, an interpretable deep learning-based algorithm called the data space landmark refiner was developed, which not only enhances both global interpretability and local interpretability but also reveals the intrinsic information of the data distribution. Using the proposed method, a type 2 diabetes mellitus diagnostic model with high interpretability was constructed on the basis of the electronic health records from two hospitals. Moreover, effective diagnostic information was directly derived from the model’s internal parameters, demonstrating strong alignment with current clinical knowledge. Compared with conventional interpretable machine learning approaches, the proposed method offered more precise and specific interpretability, increasing clinical practitioners’ trust in machine learning-supported diagnostic models.</div></div>\",\"PeriodicalId\":51063,\"journal\":{\"name\":\"Information Sciences\",\"volume\":\"690 \",\"pages\":\"Article 121582\"},\"PeriodicalIF\":8.1000,\"publicationDate\":\"2024-10-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Information Sciences\",\"FirstCategoryId\":\"94\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0020025524014968\",\"RegionNum\":1,\"RegionCategory\":\"计算机科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"0\",\"JCRName\":\"COMPUTER SCIENCE, INFORMATION SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Information Sciences","FirstCategoryId":"94","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0020025524014968","RegionNum":1,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"0","JCRName":"COMPUTER SCIENCE, INFORMATION SYSTEMS","Score":null,"Total":0}
Unveiling diagnostic information for type 2 diabetes through interpretable machine learning
The interpretability of disease prediction models is often crucial for their trustworthiness and usability among medical practitioners. Existing methods in interpretable artificial intelligence improve model transparency but fall short in identifying precise, disease-specific primal information. In this work, an interpretable deep learning-based algorithm called the data space landmark refiner was developed, which not only enhances both global interpretability and local interpretability but also reveals the intrinsic information of the data distribution. Using the proposed method, a type 2 diabetes mellitus diagnostic model with high interpretability was constructed on the basis of the electronic health records from two hospitals. Moreover, effective diagnostic information was directly derived from the model’s internal parameters, demonstrating strong alignment with current clinical knowledge. Compared with conventional interpretable machine learning approaches, the proposed method offered more precise and specific interpretability, increasing clinical practitioners’ trust in machine learning-supported diagnostic models.
期刊介绍:
Informatics and Computer Science Intelligent Systems Applications is an esteemed international journal that focuses on publishing original and creative research findings in the field of information sciences. We also feature a limited number of timely tutorial and surveying contributions.
Our journal aims to cater to a diverse audience, including researchers, developers, managers, strategic planners, graduate students, and anyone interested in staying up-to-date with cutting-edge research in information science, knowledge engineering, and intelligent systems. While readers are expected to share a common interest in information science, they come from varying backgrounds such as engineering, mathematics, statistics, physics, computer science, cell biology, molecular biology, management science, cognitive science, neurobiology, behavioral sciences, and biochemistry.