利用原子力显微镜对慢性淋巴细胞白血病细胞粘弹性接触力学进行实验和理论研究

IF 3.4 3区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY Mechanics of Materials Pub Date : 2024-10-22 DOI:10.1016/j.mechmat.2024.105186

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引用次数: 0

摘要

慢性淋巴细胞白血病（CLL）是一种通常出现在老年期的癌症。本研究提出了一种通过分析人类白细胞的几何和机械特性来检测年轻时的 CLL 细胞的方法。为此，培养了 CLL 细胞，并使用原子力显微镜 (AFM) 设备检测了它们的几何特征、粘附力和接触行为。随后，将获得的实验结果与白细胞的几何和机械特性进行了比较。此外，还利用不同的粘附和非粘附接触理论对操纵过程进行了数学建模。结果表明，与白细胞相比，血癌细胞的尺寸小 8.17%，弹性模量大 23.57%。

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Experimental and theoretical investigation of Chronic Lymphocytic Leukemia cell's viscoelastic contact mechanics using atomic force microscope

Chronic Lymphocytic Leukemia (CLL) is a type of cancer usually appearing in old age. In this research, a method for detecting CLL cells in young age through the analysis of geometrical and mechanical properties of human Leukocytes has been presented. For this purpose, the CLL cells are cultured and their geometric characteristics, adhesion force, and contact behavior have been examined using an Atomic Force Microscope (AFM) device. Subsequently, the obtained experimental results have been compared with the geometric and mechanical properties of Leukocytes. Furthermore, the manipulation process has been mathematically modeled using different adhesive and non-adhesive contact theories. The results showed that blood cancer cells have up to 8.17% smaller dimensions and up to 23.57% greater elastic modulus compared to leukocytes.

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来源期刊

Mechanics of Materials 工程技术-材料科学：综合

CiteScore

7.60

自引率

5.10%

发文量

243

审稿时长

46 days

期刊介绍： Mechanics of Materials is a forum for original scientific research on the flow, fracture, and general constitutive behavior of geophysical, geotechnical and technological materials, with balanced coverage of advanced technological and natural materials, with balanced coverage of theoretical, experimental, and field investigations. Of special concern are macroscopic predictions based on microscopic models, identification of microscopic structures from limited overall macroscopic data, experimental and field results that lead to fundamental understanding of the behavior of materials, and coordinated experimental and analytical investigations that culminate in theories with predictive quality.