{"title":"通过 N-芳基炔基磺酰胺的电化学溴化异烷基化反应进入螺融舒坦类化合物领域","authors":"Chada Raji Reddy , Maramoni Shivudu , Anjali Rathaur","doi":"10.1016/j.tetlet.2024.155330","DOIUrl":null,"url":null,"abstract":"<div><div>Synthesis of cyclohexadienone spiro-fused sultams is established through electrochemical brominative intramolecular <em>ipso</em>-annulation of <em>N-</em>aryl alkynyl sulphonamides. A range of aryl/heteroarylated-alkynyl sulphonamides are suitable under external oxidant-free electrochemical conditions. Lithium bromide is used as bromine source in this domino bromination/<em>ipso</em>-cyclization, leading to the corresponding bromo spiro-sultams in good yields.</div></div>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"An entry to spiro-fused sultams via electrochemical brominative ipso-annulation of N-aryl alkynyl sulphonamides\",\"authors\":\"Chada Raji Reddy , Maramoni Shivudu , Anjali Rathaur\",\"doi\":\"10.1016/j.tetlet.2024.155330\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Synthesis of cyclohexadienone spiro-fused sultams is established through electrochemical brominative intramolecular <em>ipso</em>-annulation of <em>N-</em>aryl alkynyl sulphonamides. A range of aryl/heteroarylated-alkynyl sulphonamides are suitable under external oxidant-free electrochemical conditions. Lithium bromide is used as bromine source in this domino bromination/<em>ipso</em>-cyclization, leading to the corresponding bromo spiro-sultams in good yields.</div></div>\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2024-10-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0040403924004258\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0040403924004258","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
An entry to spiro-fused sultams via electrochemical brominative ipso-annulation of N-aryl alkynyl sulphonamides
Synthesis of cyclohexadienone spiro-fused sultams is established through electrochemical brominative intramolecular ipso-annulation of N-aryl alkynyl sulphonamides. A range of aryl/heteroarylated-alkynyl sulphonamides are suitable under external oxidant-free electrochemical conditions. Lithium bromide is used as bromine source in this domino bromination/ipso-cyclization, leading to the corresponding bromo spiro-sultams in good yields.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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