Eman Fayad , Hanadi A. Katouah , Samah S. Abuzahrah , Ola A. Abu Ali , Arwa sultan Alqahtani , Fawziah A. Al-Salmi , Dalal Sulaiman Alshaya , Ali H. Abu Almaaty , Fahmy Gad Elsaid , N.A. Farouk , Mohamed Ahmed Elian Sophy
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Some novel synthesis 2-aroyl-1-acetylhydrazine derivatives: An assessment of their biological activity as therapeutic agents
Our study provides valuable insights into the anti-cancer activity of novel acetyl hydrazine derivatives as TOP2B inhibitors in breast cancer cells. Molecular docking studies were performed to evaluate the putative bonding mode of the synthesized compounds (3a, 4, 5a,b, and 6a,b). The obtained compounds were characterized using 1H NMR and 13C NMR. Most of the compounds exhibited significant inhibitory activity against breast cancer cell lines. Among them, compound (6b) demonstrated a remarkable anti-cancer effect by inducing G2/M phase cell cycle arrest and apoptosis.
期刊介绍：
The Journal of Molecular Structure is dedicated to the publication of full-length articles and review papers, providing important new structural information on all types of chemical species including:
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