微反应系统中过氧化氢叔丁酯和过氧化苯甲酸叔丁酯的表观动力学研究和高效连续流合成法

IF 4.1 2区 工程技术 Q2 ENGINEERING, CHEMICAL Chemical Engineering Science Pub Date : 2024-10-29 DOI:10.1016/j.ces.2024.120883
Tian Yang , Jingwei Zhang , Heng Fang , Yundong Wang , Zhuo Chen , Jianhong Xu
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引用次数: 0

摘要

本研究利用连续微反应系统推进了过氧化氢叔丁酯(TBHP)和过氧化苯甲酸叔丁酯(TBPB)的合成,通过超过 1250 个实验数据点详细阐述了动力学行为和优化过程。我们开发了一个能够进行高通量动力学实验和精确反应淬灭的平台,确定了动力学参数和最佳条件,显著提高了反应效率和安全性。我们采用了量身定制的微反应策略,包括微混合器、板式微反应器和微填料床,以管理放热反应并增强每种过氧化物的传质。对 TBHP 的条件进行了优化,使叔丁醇的转化率达到 99%,过氧化氢的转化率达到 82%,产品选择性达到 92%。对于 TBPB,在最佳条件下,苯甲酰氯的转化率达到 99.5%,TBHP 的转化率为 80%,产品选择性为 94%。将 TBHP 和 TBPB 合成工艺整合到一个单一的连续流动系统中,证明了生产的可扩展性、安全性和高效性,凸显了有机过氧化物生产的巨大发展潜力。
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Apparent kinetics study and efficient continuous-flow synthesis of tert-butyl hydroperoxide & tert-butyl peroxybenzoate in a microreaction system
This study advances the synthesis of tert-butyl hydroperoxide (TBHP) and tert-butyl peroxybenzoate (TBPB) using a continuous microreaction system, meticulously detailing kinetic behavior and optimization processes through over 1250 experimental data points. We have developed a platform capable of high-throughput kinetic experiments and precise reaction quenching, determining kinetic parameters and optimal conditions that significantly improve reaction efficiency and safety. Tailored microreaction strategies, including micro-mixers, plate microreactors, and micro-packed beds, were employed to manage exothermic reactions and enhance mass transfer for each peroxide. For TBHP, conditions were optimized to achieve a 99% conversion rate of tert-butanol and an 82% conversion of hydrogen peroxide, with product selectivity reaching 92%. For TBPB, under optimal conditions, benzoyl chloride conversion reached 99.5%, and TBHP conversion was 80%, with a product selectivity of 94%. The integration of the TBHP and TBPB synthesis processes into a single continuous-flow system demonstrates scalable, safe, and efficient production, highlighting significant potential for advancements in organic peroxide manufacturing.
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来源期刊
Chemical Engineering Science
Chemical Engineering Science 工程技术-工程:化工
CiteScore
7.50
自引率
8.50%
发文量
1025
审稿时长
50 days
期刊介绍: Chemical engineering enables the transformation of natural resources and energy into useful products for society. It draws on and applies natural sciences, mathematics and economics, and has developed fundamental engineering science that underpins the discipline. Chemical Engineering Science (CES) has been publishing papers on the fundamentals of chemical engineering since 1951. CES is the platform where the most significant advances in the discipline have ever since been published. Chemical Engineering Science has accompanied and sustained chemical engineering through its development into the vibrant and broad scientific discipline it is today.
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