眼眶视网膜母细胞瘤对单用持续性全身化疗的意外反应

IF 0.5 Q4 OPHTHALMOLOGY Case Reports in Ophthalmology Pub Date : 2024-10-29 eCollection Date: 2024-01-01 DOI:10.1159/000541776

Khitam F Alhasseny, Haseeb Mahmud, Mohannad Al-Samarraie

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引用次数: 0

摘要

导言：一名16个月大的女孩患上了双侧种系视网膜母细胞瘤，右眼为晚期视网膜母细胞瘤，左眼为严重的眼眶视网膜母细胞瘤。患者通常接受由化疗、手术和放疗组成的多模式治疗方案，该方案提高了患者的生存率：我们的患者选择了内科治疗和全身化疗，而不是眼球摘除术或眼球摘除术。她接受了由硫酸长春新碱、磷酸依托泊苷和卡铂组成的三组全身化疗，由于依从性差，三组化疗的间隔时间长达三年。化疗后，她的双眼肿瘤消退，13 年后没有活动性疾病的迹象：本病例代表了眼眶视网膜母细胞瘤治疗的一个有趣的良好结果，尽管与传统的多模式方案相比，单用全身化疗并不一致。

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An Unexpected Response of Orbital Retinoblastoma to Inconsistent Systemic Chemotherapy Alone.

Introduction: A 16-month-old girl presented with bilateral germline retinoblastoma, with advanced retinoblastoma in the right eye and severe orbital retinoblastoma in the left eye. Patients typically receive treatment with the multimodal protocol consisting of chemotherapy, surgery, and radiotherapy, which has improved survival.

Case presentation: Our patient elected for medical management with systemic chemotherapy instead of enucleation or exenteration. She received three blocks systemic chemotherapy consisting of vincristine sulfate, etoposide phosphate, and carboplatin, with irregular intervals between blocks over 3 years, due to poor compliance. Following chemotherapy, she had tumor regression in both eyes and no signs of active disease 13 years later.

Conclusion: This case represents an interesting favorable outcome of orbital retinoblastoma management with systemic chemotherapy alone despite inconsistency versus conventional multimodal protocol.

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来源期刊

Case Reports in Ophthalmology OPHTHALMOLOGY-

CiteScore

0.90

自引率

0.00%

发文量

129

审稿时长

12 weeks

期刊介绍： This peer-reviewed online-only journal publishes original case reports covering the entire spectrum of ophthalmology, including prevention, diagnosis, treatment, toxicities of therapy, supportive care, quality-of-life, and survivorship issues. The submission of negative results is strongly encouraged. The journal will also accept case reports dealing with the use of novel technologies, both in the arena of diagnosis and treatment. Supplementary material is welcomed. The intent of the journal is to provide clinicians and researchers with a tool to disseminate their personal experiences to a wider public as well as to review interesting cases encountered by colleagues all over the world. Universally used terms can be searched across the entire growing collection of case reports, further facilitating the retrieval of specific information. Following the open access principle, the entire contents can be retrieved at no charge, guaranteeing easy access to this valuable source of anecdotal information at all times.