RhoGEFs的Dbl家族在机械传导中的作用--综述。

IF 4.6 2区 生物学 Q2 CELL BIOLOGY Frontiers in Cell and Developmental Biology Pub Date : 2024-10-16 eCollection Date: 2024-01-01 DOI:10.3389/fcell.2024.1485725
Kazumasa Ohashi, Aoi Kunitomi, Shuhei Chiba, Kensaku Mizuno
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引用次数: 0

摘要

Rho 鸟嘌呤核苷酸交换因子(RhoGEFs)由多种蛋白质组成,其共同结构域负责激活 Rho 家族的小 GTP 酶,其他结构域则各不相同。RhoGEFs 的进化分化使肌动蛋白细胞骨架得以重组,从而导致高等生物体内复杂的细胞反应。在本综述中,我们将探讨 RhoGEFs 参与哺乳动物细胞机械应激反应的情况。细胞的机械应激反应对于细胞群的正常有序调节至关重要,包括维持稳态、组织形态发生和适应机械环境。本综述特别关注最近关于参与细胞-细胞和细胞-基质粘附位点机械应激反应的 RhoGEFs Dbl 家族的研究结果,以及它们作为肌动蛋白细胞骨架重塑和信号转导基础的分子机制。
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Roles of the Dbl family of RhoGEFs in mechanotransduction - a review.

Rho guanine nucleotide exchange factors (RhoGEFs) comprise a wide range of proteins with a common domain responsible for the activation of the Rho family of small GTPases and various domains in other regions. The evolutionary divergence of RhoGEFs enables actin cytoskeletal reorganization, leading to complex cellular responses in higher organisms. In this review, we address the involvement of RhoGEFs in the mechanical stress response of mammalian cells. The cellular mechanical stress response is essential for the proper and orderly regulation of cell populations, including the maintenance of homeostasis, tissue morphogenesis, and adaptation to the mechanical environment. In particular, this review focuses on the recent findings regarding the Dbl family of RhoGEFs involved in mechanical stress responses at the cell-cell and cell-substrate adhesion sites, and their molecular mechanisms underlying actin cytoskeleton remodeling and signal transduction.

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来源期刊
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology Biochemistry, Genetics and Molecular Biology-Cell Biology
CiteScore
9.70
自引率
3.60%
发文量
2531
审稿时长
12 weeks
期刊介绍: Frontiers in Cell and Developmental Biology is a broad-scope, interdisciplinary open-access journal, focusing on the fundamental processes of life, led by Prof Amanda Fisher and supported by a geographically diverse, high-quality editorial board. The journal welcomes submissions on a wide spectrum of cell and developmental biology, covering intracellular and extracellular dynamics, with sections focusing on signaling, adhesion, migration, cell death and survival and membrane trafficking. Additionally, the journal offers sections dedicated to the cutting edge of fundamental and translational research in molecular medicine and stem cell biology. With a collaborative, rigorous and transparent peer-review, the journal produces the highest scientific quality in both fundamental and applied research, and advanced article level metrics measure the real-time impact and influence of each publication.
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