Carolyn A Young, David J Rog, Basil Sharrack, Radu Tanasescu, Seema Kalra, Suresh K Chhetri, Lisa Wilde, Roger J Mills, Alan Tennant
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引用次数: 0
摘要
背景:MSIS-29测量多发性硬化症的生理和心理影响:MSIS-29测量多发性硬化症对身体和心理的影响:目的:研究MSIS-29各领域与人口学/临床方面的关联,并分析随时间变化的轨迹:方法:在 "神经系统疾病结果轨迹研究"(Trajectories of Outcome in Neurological Conditions study)中收集了不同多发性硬化症患者的数据,并进行了长达5年的随访。在进行拉施分析后,计算了随后的总体、身体和心理领域的最小重要变化(MIC):结果:利用 5921 名参与者的数据对 Rasch 模型进行拟合,验证了身体、心理和总领域,转换表将原始分数转换为区间水平的度量等值。这些领域在不同的人口统计学因素(年龄、性别、就业、教育和婚姻状况)和临床因素(亚型、治疗和持续时间)之间存在显著差异,且效应大小较大。MIC 分数分别为:身体:9.1 分,总分:14.1 分,均高于测量误差,心理:5.5 分,低于测量误差,因此有 1.6% 的参与者报告了心理变化,这在临床上具有重要意义,但在统计上并不显著。轨迹分析显示有三组,一组稳定,两组有明显的斜率,分别为改善和恶化:MSIS-29在通过双因素解决方案解决了局部项目依赖问题后,显示出与Rasch模型的充分拟合。各领域在关键因素之间表现出良好的区分度。
Physical and psychological aspects of multiple sclerosis: Revisiting the Multiple Sclerosis Impact Scale (MSIS-29).
Background: The MSIS-29 measures the physical and psychological impact of MS.
Objective: The associations between MSIS-29 domains and demographic/clinical aspects were examined and trajectories analysed over time.
Methods: Data were collected in the Trajectories of Outcome in Neurological Conditions study for a diverse population of people with MS, with follow-up for up to 5 years. Following Rasch analysis, minimal important change (MIC) was computed for ensuing total, physical and psychological domains.
Results: Fit to the Rasch model using data from 5921 participants validated physical, psychological and total domains, and the conversion table transforms raw scores to interval-level metric equivalents. These domains showed significant differences across demographic (age, gender, employment, education, and marital status) and clinical (subtype, treatment, and duration) factors with large effect sizes. The MIC scores were physical: 9.1, total: 14.1, which were both above measurement error, and psychological: 5.5 which was not, so 1.6% of participants reported psychological change which was clinically important but not statistically significant. Trajectory analysis showed three groups, one stable and two with significant slopes, improving and deteriorating.
Conclusion: The MSIS-29 has shown adequate fit to the Rasch model after accommodating problems with local item dependency, through a bi-factor solution. The domains showed good discrimination across key factors.
期刊介绍:
Multiple Sclerosis Journal is a peer-reviewed international journal that focuses on all aspects of multiple sclerosis, neuromyelitis optica and other related autoimmune diseases of the central nervous system.
The journal for your research in the following areas:
* __Biologic basis:__ pathology, myelin biology, pathophysiology of the blood/brain barrier, axo-glial pathobiology, remyelination, virology and microbiome, immunology, proteomics
* __Epidemology and genetics:__ genetics epigenetics, epidemiology
* __Clinical and Neuroimaging:__ clinical neurology, biomarkers, neuroimaging and clinical outcome measures
* __Therapeutics and rehabilitation:__ therapeutics, rehabilitation, psychology, neuroplasticity, neuroprotection, and systematic management
Print ISSN: 1352-4585