异质核糖核蛋白 K 是增强鼻咽癌化疗敏感性的潜在靶点。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-10-30 eCollection Date: 2024-01-01 DOI:10.1515/biol-2022-0975
Ming Yang, Zhaoyang Ke, Daji Wang
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引用次数: 0

摘要

肿瘤细胞对化疗药物的耐药性是鼻咽癌复发和转移的关键因素。因此,找到能提高鼻咽癌细胞对化疗药物敏感性的有效生物靶点至关重要。异质核糖核蛋白K(hnRNPK)在调节各种肿瘤类型的化疗耐药性方面发挥着核心作用。然而,它在鼻咽癌细胞中的具体功能仍不清楚。本研究揭示了 hnRNPK 在鼻咽癌组织中的过表达,而在正常鼻咽组织中的弱表达。hnRNPK 的表达水平与鼻咽癌患者的存活率呈负相关。重要的是,敲除 hnRNPK 后,鼻咽癌细胞对顺铂的敏感性显著增加,这证明 hnRNPK 是鼻咽癌化疗耐药性的关键诱导因子。从机理上讲,hnRNPK通过抑制Akt/caspase 3通路的激活来诱导鼻咽癌细胞产生化疗耐药性。在鼻咽癌肿瘤小鼠中,敲除hnRNPK可提高顺铂化疗的疗效。因此,这项研究为提高鼻咽癌细胞对化疗的敏感性找到了一个潜在靶点。
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Heterogeneous nuclear ribonucleoprotein K is a potential target for enhancing the chemosensitivity of nasopharyngeal carcinoma.

The resistance of tumor cells to chemotherapy drugs is a critical determinant in the recurrence and metastasis of nasopharyngeal carcinoma (NPC). Therefore, it is crucial to identify effective biotargets that can enhance the sensitivity of NPC cells to chemotherapy drugs. Heterogeneous nuclear ribonucleoprotein K (hnRNPK) plays a central role in regulating chemotherapy resistance across various tumor types. However, its specific function in NPC cells remains unclear. This study reveals that hnRNPK is overexpressed in NPC tissues while weakly expressed in normal nasopharyngeal tissues. The expression level of hnRNPK is negatively associated with NPC patient survival. Importantly, hnRNPK is a key inducer of chemotherapy resistance in NPC, as evidenced by the significant increase in NPC cell sensitivity to cisplatin following hnRNPK knockdown. Mechanistically, hnRNPK induces chemotherapy resistance in NPC cells by suppressing the activation of the Akt/caspase 3 pathway. In NPC tumor-bearing mice, hnRNPK knockdown enhances the efficacy of cisplatin chemotherapy. Consequently, this work identifies a potential target for enhancing the sensitivity of NPC cells to chemotherapy.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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