舒戈欣 1 在各种癌症中的表达:潜在的治疗靶点。

IF 2.8 3区 医学 Q2 ONCOLOGY Clinical & Translational Oncology Pub Date : 2024-10-30 DOI:10.1007/s12094-024-03749-1
Indumathi Ankathatti Narayanaswamy, Abhay Kumaraswamy Kattepur, Kalyani Raju, Venkatachalam Perumal, Ravi Ramalingam, Venkateswarlu Raavi
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引用次数: 0

摘要

据报道,舒戈欣 1(SGO1)是舒戈欣(守护神)家族蛋白之一,主要参与细胞分裂过程中中心粒的保护和染色体的正常分离。最近的研究发现,SGO1 的表达改变与多种癌症和遗传疾病有关,并建议将其作为治疗靶点。在本研究中,我们回顾了现有文献中有关 SGO1 基因和蛋白在各种癌细胞系、动物模型和癌症患者中的表达,以及用 siRNA/shRNA 靶向 SGO1 的研究。在前列腺癌、肾癌、肺癌、乳腺癌、神经母细胞瘤、白血病、肝癌和结肠癌细胞系中,我们观察到 SGO1 mRNA 和蛋白水平的表达明显增加,而且其水平与细胞增殖、侵袭和转移的增加有关。与野生型相比,在 SGO1 基因敲除/单倍体不足的小鼠中观察到了 SGO1 水平的改变,而这一水平与染色体不稳定性和肿瘤发生的增加有关。与细胞系一致,在癌症患者的肿瘤组织中也观察到 SGO1 的表达高于邻近的正常组织,而且其水平与肿瘤分期、分级、大小和激素状态呈正相关。SGO1 的高表达与对化疗药物的耐药性有关,而 SGO1 的敲除会增加对这些药物的敏感性。此外,用 siRNA/shRNA 靶向 SGO1 可减少 SGO1 的表达和增殖,并诱导癌细胞凋亡。总之,SGO1在各种癌症中的表达水平都明显较高,而用siRNA和shRNA靶向SGO1可以降低SGO1的水平,减少癌症的增殖和转移。
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Shugoshin 1 expression in various cancers: a potential target for therapy.

Shugoshin 1 (SGO1) is one of the Shugoshin (guardian spirit) family proteins, which is reported to be majorly involved in the protection of centromeres and proper segregation of chromosomes during cell division. Recent studies found that the altered expression of SGO1 is associated with various cancers and genetic disorders, and suggested as a target for therapy. In the present study, we have reviewed the available literature on SGO1 gene and protein expression in various cancer-cell lines, animal models and cancer patients, and targeting SGO1 with siRNA/shRNA. A significant increase in the expression of SGO1 mRNA and protein levels were observed in prostate, renal, lung, breast, neuroblastoma, leukemia, hepatocellular, and colon cancer-cell lines and the levels were associated with increased cellular proliferation, invasion, and metastasis. The altered SGO1 levels were observed in SGO1 knockout/haploinsufficient mice compared to wild type and the levels were associated with increased chromosome instability and tumorigenesis. Consistent with cell lines, higher SGO1 expression was also observed in tumor tissues of cancer patients compared to adjacent normal tissue and the levels were positively correlated with tumor stage, grade, size, and hormonal status. Higher SGO1 expression was related to resistance to chemotherapeutic agents and the knockdown of SGO1 increased sensitivity to those agents. Furthermore, targeting SGO1 with siRNA/shRNA reduced the expression of SGO1 and proliferation, and induced apoptosis of cancer cells. Overall, the SGO1 expression levels were significantly higher in various cancers, and targeting SGO1 with siRNA and shRNA reduced the levels of SGO1, proliferation and metastasis of cancers.

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来源期刊
CiteScore
6.20
自引率
2.90%
发文量
240
审稿时长
1 months
期刊介绍: Clinical and Translational Oncology is an international journal devoted to fostering interaction between experimental and clinical oncology. It covers all aspects of research on cancer, from the more basic discoveries dealing with both cell and molecular biology of tumour cells, to the most advanced clinical assays of conventional and new drugs. In addition, the journal has a strong commitment to facilitating the transfer of knowledge from the basic laboratory to the clinical practice, with the publication of educational series devoted to closing the gap between molecular and clinical oncologists. Molecular biology of tumours, identification of new targets for cancer therapy, and new technologies for research and treatment of cancer are the major themes covered by the educational series. Full research articles on a broad spectrum of subjects, including the molecular and cellular bases of disease, aetiology, pathophysiology, pathology, epidemiology, clinical features, and the diagnosis, prognosis and treatment of cancer, will be considered for publication.
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