病例报告:关于利奈唑胺在一名儿童患者中引起的牙齿变色的病例研究和文献综述,利奈唑胺潜伏期最短。

IF 2.1 3区 医学 Q2 PEDIATRICS Frontiers in Pediatrics Pub Date : 2024-10-15 eCollection Date: 2024-01-01 DOI:10.3389/fped.2024.1440322
Sun Le-le, Zhao Qun, Qi Lei, Meng Xiangwei, Si Jigang
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引用次数: 0

摘要

背景:说到利奈唑胺的不良反应,人们想到的主要是恶心、呕吐、骨髓抑制等。很少有人知道牙齿变色这种罕见的不良反应:我们描述了一例细菌性脑膜炎患儿的病例。入院后,给予头孢曲松和利奈唑胺联合抗感染,并使用地塞米松抑制炎症反应。在使用利奈唑胺治疗的第 5 天,患儿的牙齿出现褐色,且无法通过正常的口腔清洁去除。经查阅药品说明书和文献,发现牙齿变色是利奈唑胺的一种罕见不良反应,属于假性变色。停药 28 天或最长 5 个月后,即可恢复正常颜色。对患者的生活没有明显影响,因此可继续使用利奈唑胺完成抗感染疗程:抗感染治疗14天后,患儿炎症指标降至正常,出院前病情接近恢复。停药 28 天后,牙齿颜色恢复正常:结论:这一罕见的不良反应揭示了这种广泛使用的抗生素以前从未报道过的副作用。在我们的病例中,牙齿变色发生较早,更新了不良反应的潜伏期。
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Case Report: A case study and literature review on teeth discoloration caused by linezolid with the shortest incubation period in a pediatric patient.

Background: When it comes to the adverse reactions of linezolid, people always call to mind primarily nausea, vomiting, bone marrow suppression, and so on. Few people are aware of the rare adverse reaction of teeth discoloration.

Case presentation: We describe the case of a child affected by bacterial meningitis. After admission, a combination of ceftriaxone and linezolid was administered for anti-infection, and dexamethasone was used to inhibit inflammatory reactions. On the 5th day of treatment with linezolid, the child's teeth appeared brownish color and could not be removed with normal oral hygiene. Upon reviewing the drug instructions and literature, it was found that the discoloration of teeth is a rare adverse reaction of linezolid, which is pseudo discoloration. After stopping the medication for 28 days or up to 5 months, the normal color can be restored. There is no significant impact on the life of the patient, therefore, continue to use linezolid to complete the anti-infection course.

Results: After 14 days of anti-infection treatment, the inflammatory indicators of the child decreased to normal, and the condition was close to recovery before discharge. After stopping the medication for 28 days, the color of the teeth returned to normal.

Conclusions: This rare adverse reaction sheds light on a previously unreported side effect of this widely used antibiotic. In our case, the discoloration of the teeth occurred earlier, updating the latent period of the adverse reaction.

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来源期刊
Frontiers in Pediatrics
Frontiers in Pediatrics Medicine-Pediatrics, Perinatology and Child Health
CiteScore
3.60
自引率
7.70%
发文量
2132
审稿时长
14 weeks
期刊介绍: Frontiers in Pediatrics (Impact Factor 2.33) publishes rigorously peer-reviewed research broadly across the field, from basic to clinical research that meets ongoing challenges in pediatric patient care and child health. Field Chief Editors Arjan Te Pas at Leiden University and Michael L. Moritz at the Children''s Hospital of Pittsburgh are supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Pediatrics also features Research Topics, Frontiers special theme-focused issues managed by Guest Associate Editors, addressing important areas in pediatrics. In this fashion, Frontiers serves as an outlet to publish the broadest aspects of pediatrics in both basic and clinical research, including high-quality reviews, case reports, editorials and commentaries related to all aspects of pediatrics.
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