诱导原生噬菌体鸡尾酒用于治疗耐药性疾病中的多微生物激活综合征。

IF 1 Q3 MEDICINE, GENERAL & INTERNAL Cureus Pub Date : 2024-10-28 eCollection Date: 2024-10-01 DOI:10.7759/cureus.72587
David A Jernigan
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引用次数: 0

摘要

全球人口饱受多种慢性疾病的困扰,部分原因是许多潜伏微生物的毒力被激活,导致慢性多系统疾病,由此产生了一个新名词--多微生物激活综合征(MMAS)。目前,整个微生物谱系中的耐药性感染在很大程度上已无法用以前成功的药物和自然疗法来治疗。长期使用化学治疗抗生素、抗真菌剂和抗病毒药物等严厉的方法,其不良反应可能比原来的疾病更严重,但从长远来看,这些方法目前基本上毫无用处,因为微生物已经发生了快速的适应性突变,产生了耐药性。诱导原生噬菌体疗法的引入开创了一个全新的治疗类别,有可能补充或取代多种类型的积极药物疗法。自问世以来,这项技术取得了许多进展。这种新疗法的最新进展是能够配制出诱导原生噬菌体鸡尾酒,在配方中使用广泛的诱导特征,刺激已经生活在体内噬菌体组中的各种有益噬菌体,以针对各种病原微生物和相关的有利生理靶点。在同一种配方中同时解决各种慢性疾病中常见的 MMAS 问题,能够在不损害微生物组或人体组织和系统的情况下取得更好的临床效果。
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Induced Native Phage Cocktails for Multi-microbial Activation Syndrome in Treatment-Resistant Illnesses.

The global population is plagued by chronic illnesses of many types due to, in part, the activation of virulence of many latent microbes leading to chronic multi-system illness, stimulating the new term, multi-microbial activation syndrome (MMAS). Treatment-resistant infections across the entire microbial spectrum are now largely untreatable using the previously successful pharmaceutical and natural medicine options. The heavy-handed methods of long-term chemotherapeutic antibiotics, antifungals, and antiviral drugs, whose adverse effects could be worse than the original illness, are presently essentially useless in the long run, as microbes have developed rapid adaptive mutations, becoming drug-resistant. The introduction of induced native phage therapy opened a completely new treatment category that has the potential to complement or replace aggressive drug therapies of many classes. Since its introduction, many advancements have been made to the technology. The most recent development in this new treatment genre is the ability to formulate induced native phage cocktails that use a wide spectrum of induction signatures within the formulation to stimulate various types of beneficial phages already living within the phageome of the body, to target a wide range of pathogenic microbes and associated advantageous physiological targets. The ability to address the MMAS commonly seen in various chronic illnesses simultaneously within the same formulation enables greater clinical outcomes without harm to the microbiome or to the tissues and systems of the body.

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